Knowledge Tree
skin aging
Also known as: skin ageing, aging skin, skin anti-aging
Facts (19)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 15 facts
claimApplying antioxidants to neutralize free radicals is a method to slow skin aging, and the administration of natural products, particularly polyphenols with antioxidative properties, can enhance or remove undesirable signs of skin aging.
claimNicotinamide mononucleotide (NMN) protects skin cells, such as keratinocytes, from UV radiation-caused DNA damage by enhancing DNA repair, which contributes to reversing skin ageing.
claimTopical or oral use of polyphenol-rich plants can prevent or reduce undesirable conditions of skin aging.
claimA tetrahedral framework DNA-based bioswitchable miRNA inhibitor delivery system has been developed for application to skin anti-aging.
claimCOL17A1 plays a role in epidermal stem cell (EpSC) competition to orchestrate skin homeostasis and aging, and COL17A1 overexpression helps combat skin aging.
claimStem cell competition orchestrates skin homeostasis and ageing.
claimSunscreen, retinoids, and resveratrol are foundational topical cosmetics used to combat skin aging, though the relationship between their effectiveness in preventing skin aging is unclear.
claimThe dedifferentiation of aged epidermal cells into epidermal stem cells (EpSCs) offers potential for reversing skin aging and promoting wound repair.
claimSenescent skin cells, senescence-associated secretory phenotype (SASP), oxidative stress, inflammation, and autophagy mediate the pathophysiology of skin ageing.
claimThe miR-31-CLOCK-ERK pathway contributes to skin aging and serves as a therapeutic target; inhibiting this pathway, via conditional miR-31 ablation or MAPK/ERK inhibitors, can delay the skin aging process.
claimSkin ageing is a multifactorial process influenced by intrinsic variables (time, genetics, hormones) and extrinsic variables (UV exposure, pollution).
claimY27632 and apocynin are COL17A1-inducing drugs that facilitate skin regeneration and reduce skin aging.
claimA stress-induced miR-31–CLOCK–ERK pathway acts as a key driver and therapeutic target for skin aging.
claimMiR-31 inhibitors-loaded BiRDS (Bi-responsive delivery systems) demonstrate excellent skin penetration and high RNA delivery efficiency, which helps combat skin aging.
claimTargeting the activation of COL17A1 is a potential therapeutic intervention for skin anti-aging.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu 1 fact
claimResveratrol acts as a factor that prevents skin aging and affects skin regeneration, according to a 2022 study by Leis, K., Pisanko, K., Jundziłł, A., Mazur, E., Męcińska-Jundziłł, K., and Witmanowski, H.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
referenceSkin aging involves specific pathophysiology and innovative therapies, as reviewed by Boismal et al. (2020).
Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua 1 fact
referenceLeis et al. (2022) examined resveratrol as a factor for preventing skin aging and affecting skin regeneration.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 1 fact
claimSilybin prevents or manages advanced glycation end product (AGE)-mediated pathologies related to skin aging.