concept

sirtuins

Also known as: SIRTs

Facts (10)

Sources

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 4 facts

referenceThe article 'Sirtuins and cellular senescence in patients with idiopathic pulmonary fibrosis and systemic autoimmune disorders' published in Drugs in 2024 (84:491–501) investigates sirtuins and cellular senescence in patients with idiopathic pulmonary fibrosis and systemic autoimmune disorders.

referenceThe article 'NAD(+), sirtuins, and cardiovascular disease' published in Current Pharmaceutical Design in 2009 (15:110–7) discusses the roles of NAD(+) and sirtuins in cardiovascular disease.

referenceThe article 'Acetylome regulation by sirtuins in the brain: from normal physiology to aging and pathology' published in Current Pharmaceutical Design discusses how sirtuins regulate the acetylome in the brain across normal physiology, aging, and pathology.

referenceChandramowlishwaran, P., Vijay, A., Abraham, D., Li, G., Mwangi, S., Srinivasan, S. (2020) examined the role of sirtuins in modulating neurodegeneration of the enteric nervous system and central nervous system, published in Frontiers in Neuroscience.

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 3 facts

claimSirtuins are activated following an increased NAD+/NADH ratio, which occurs during energy starvation such as glucose depletion.

claimSirtuins contribute to cell fate transition and have been implicated in enhancing the generation of induced pluripotent stem cells (iPSCs).

claimSirtuins act as histone deacetylases (HDAC) to achieve transcriptional silencing.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 2 facts

claimNAD+ facilitates nuclear DNA repair by acting as a substrate for PARP and SIRTs and providing adenylate for DNA ligase IV.

referenceSirtuins, melatonin, and circadian rhythms are interconnected in the context of aging and cancer, as discussed by Jung-Hynes, Reiter, and Ahmad in the Journal of Pineal Research (2010).

Antiageing strategy for neurodegenerative diseases - Nature nature.com Nature Mar 10, 2025 1 fact

referenceThe sirtuin family of proteins plays a significant role in health and disease, as reviewed by Wu et al. in Signal Transduction and Targeted Therapy (2022).