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self-renewal
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Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org 8 facts
claimIntestinal stem cells (ISCs) that cannot oxidize glucose in the tricarboxylic acid (TCA) cycle exhibit enhanced proliferation and self-renewal.
claimBoth a high-fat diet and intermittent fasting lead to intestinal stem cell-autonomous activation of PPARδ signaling, which enhances self-renewal through partial activation of a Wnt signaling program and enhanced fatty acid oxidation.
claimHigh-fat diets enhance stemness through enforcing self-renewal via microbiota-derived butyrate, while ketogenesis enhances stemness via β-OHB accumulation.
claimWhile metabolites from a high-fat diet can promote self-renewal in tissue stem cells, the diet is likely to alter stem cells in ways that skew their fates or exacerbate their response to inflammation in many contexts.
claimOncogenic mutations lock stem cells in states of ongoing self-renewal, which facilitates tumorigenesis, leading to the recognition of stem cells as the root of malignancy.
referenceBlocking glucose entry into the tricarboxylic acid (TCA) cycle in intestinal stem cells (ISCs) enhances their self-renewal (Schell et al. 2017; Bensard et al. 2020).
claimDietary changes induce critical shifts in glucose and fatty acid metabolism, which may cell-intrinsically coordinate self-renewal and differentiation in stem cells and their niche partners.
claimGenetic inhibition of glucose oxidation enhances intestinal stem cell (ISC) self-renewal, serving as an orthogonal method to enhance ISC fatty acid oxidation, as reported by Bensard et al. (2020).
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 3 facts
claimHematopoietic stem cells (HSCs) display enhanced self-renewal potential under conditions of low reactive oxygen species (ROS) content.
claimMitochondrial metabolism is important for the self-renewal of human pluripotent stem cells (PSCs), as evidenced by increased activation when lipid levels in the culture media are reduced.
referenceDistinct metabolic states can support self‐renewal and lipogenesis in human pluripotent stem cells under different culture conditions, according to Zhang et al. in Cell Reports in 2016.