Knowledge Tree
SARS-CoV-2
Also known as: COVID-19, SARS-COV2
Facts (20)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 6 facts
claimInfluenza A and SARS-CoV-2 infections cause high viral replication in respiratory epithelial cells and mediate an aggressive inflammatory response that damages lung cells.
claimIn the context of SARS-CoV-2 infection, the cytokines IL-12 and IL-8 enhance IFN-γ production, which attracts monocytes and T lymphocytes, but not neutrophils, to induce apoptosis and eliminate infected cells.
claimDuring viral infections such as SARS-CoV-2, RSV, Parvovirus B19, and Influenza, levels of pro-inflammatory cytokines are elevated and decrease upon viral clearance.
referenceThe article 'Induction of Pro-Inflammatory Cytokines (IL-1 and IL-6) and Lung Inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-Inflammatory Strategies' was published in the Journal of Biological Regulators and Homeostatic Agents in 2020 (Volume 34, pages 327-331).
claimCytokine storms are believed to be a major cause of morbidity and mortality in SARS-CoV-2 infections.
claimSARS-CoV-2 causes severe lung damage primarily through overstimulation of the immune system, leading to massive and uncontrollable inflammation, rather than through viral spreading.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 5 facts
claimSilybin, an active constituent found in Silybum marianum, exhibited higher binding affinity with targets in SARS-CoV-2 compared to existing drugs against SARS-CoV-2.
claimTreatment with Glycyrrhiza glabra root extract causes a significant decrease in ACE2 expression in the small intestine, which may represent an entry point for transport of nutrients SARS-CoV-2.
claimEssential oils and extracts of Ocimum genus species contain inhibitors of glycoprotein adhesion on the surface of SARS-CoV-2, which prevent viral replication and strengthen the immune system.
claimPhyto-compounds from Vitex negundo, specifically oleanolic acid, ursolic acid, 3b-acetoxyolean-12-en-27-oic acid, and isovitexin, interact with the PLpro via hydrogen bonds, making them potential drug molecules for treating SARS-CoV-2.
referenceA study published in Journal of Biomolecular Structure and Dynamics (Vol 40, pp 5665-5686) investigated compounds against the papain-like protease (PLpro) of SARS-CoV-2 to address the COVID-19 pandemic.
A Double-Edged Sword: Inflammation and Your Health - Cedars-Sinai cedars-sinai.org Feb 12, 2021 4 facts
accountMoshe Arditi began investigating the SARS-CoV-2 superantigen after observing reports of multisystem inflammatory syndrome in children (MIS-C) in pediatric COVID-19 patients.
claimMoshe Arditi hypothesized that discovering protein-level similarities between SARS-CoV-2 and the bacterial structure causing toxic shock syndrome could improve treatments for both MIS-C patients and adults with COVID-19 experiencing cytokine storms.
claimMoshe Arditi, the director of the Cedars-Sinai Pediatric Infectious Diseases and Immunology Division, identified a protein within SARS-CoV-2 called a superantigen that can trigger an immune system overdrive similar to toxic shock syndrome.
claimMoshe Arditi's research team utilized a computer model to analyze the interaction between the SARS-CoV-2 superantigen protein and T cells.
Construction of Knowledge Graphs: State and Challenges - arXiv arxiv.org 1 fact
claimThe Drug Repurposing Knowledge Graph (DRKG) applies link prediction using graph embeddings with the TransE model to predict relations between drugs, genes, and the diseases SARS, MERS, and SARS-COV2 (COVID-19).
Medicinal plants meet modern biodiversity science - OUCI ouci.dntb.gov.ua 1 fact
claimHussain proposed antiviral species of the genus Artemisia (Asteraceae-Anthemideae) as candidate taxa for treating SARS-CoV-2 (COVID-19) based on a phylogenetic perspective.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
referenceNaidu et al. (2023) published a study identifying plant-derived natural non-nucleoside analog inhibitors (NNAIs) that target the RNA-dependent RNA polymerase complex (nsp7/nsp8/nsp12) of SARS-CoV-2.
Comprehensive Overview on the Present State and Evolution of ... link.springer.com Aug 9, 2024 1 fact
referenceKamyab, H., Naderipour, A., Jahannoush, M., Abdullah, A., and Marzbali, M.H. published a study in 2022 titled 'Potential effect of SARS-CoV-2 on solar energy generation: Environmental dynamics and implications' in the journal Sustainable Energy Technologies and Assessments.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu 1 fact
referenceH. Jiang, P. Yang, and J. Zhang published a 2022 study in Frontiers in Chemistry identifying potential inhibitors targeting the papain-like protease of SARS-CoV-2.