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resting membrane potential
Also known as: resting potential, cellular resting membrane potential
Facts (18)
Sources
Neuroanatomy, Neuron Action Potential - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 5 facts
claimDepolarization occurs when the resting membrane potential becomes less negative, while hyperpolarization occurs when the resting membrane potential becomes more negative.
measurementThe resting membrane potential of a neuron is approximately -60mV, characterized by the cell's interior being negative compared to the outside.
measurementThe resting membrane potential of a neuron is -60 mV.
claimThe resting membrane potential is maintained by an unequal distribution of ions across the cellular membrane, established by ATP-dependent pumps, most notably sodium-potassium antiporters.
procedureThe generation of an action potential occurs in three stages: (1) depolarization, which changes the membrane potential from -60 mV to +40 mV primarily through sodium influx; (2) repolarization, which returns the membrane to its resting potential primarily through potassium efflux; and (3) after-hyperpolarization, which involves recovery from a slight overshoot of the repolarization phase.
Action potential: Definition, Steps, Phases | Kenhub kenhub.com 5 facts
claimDuring early repolarization, the generation of a new action potential is impossible because sodium channels are inactive and require the resting potential to return to a closed state before they can open again.
claimDuring the repolarization phase, sodium permeability decreases due to the closing of sodium channels, and voltage-gated potassium channels open, causing a large potassium efflux that decreases the cell's electropositivity to restore the resting membrane potential.
claimAn action potential is defined as a sudden, fast, transitory, and propagating change of the resting membrane potential.
measurementIn excitable tissues, the threshold potential is approximately 10 to 15 mV less than the resting membrane potential.
claimHyperpolarization is a state in which the membrane potential is more negative than the default resting membrane potential, and it follows the repolarization phase.
Bioelectricity | Department of Biology - School of Arts and Sciences as.tufts.edu 2 facts
referenceBonzanni, M. and Payne, S. defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential.
referenceResting membrane potential can be measured using the fluorescent voltage reporters DiBAC4(3) and CC2-DMPE, according to protocols by Adams and Levin in Cold Spring Harbor Protocols (2012).
Neuron action potentials: The creation of a brain signal (article) khanacademy.org 2 facts
Peer-Reviewed Papers - The Levin Lab drmichaellevin.org 1 fact
referenceDepolarization of cellular resting membrane potential promotes neonatal cardiomyocyte proliferation in vitro.
Action potentials and synapses - Queensland Brain Institute qbi.uq.edu.au 1 fact
measurementThe resting membrane potential of a neuron is approximately -70 mV, meaning the inside of the cell is more negative than the outside.
Bioelectricity - The Levin Lab drmichaellevin.org 1 fact
referenceGeneral principles for measuring resting membrane potential and ion concentration using fluorescent bioelectricity reporters were published by Adams and Levin in Cold Spring Harbor Protocols (2012).
Branching morphology determines signal propagation dynamics in ... nature.com Aug 21, 2017 1 fact
measurementThe resting potential in the Hodgkin-Huxley model simulation was set to -65 mV.