concept

reprogramming

Also known as: reprogramming strategies

Facts (9)

Sources

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 5 facts

referenceJang et al. (2012) reported that O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network.

referenceERRs mediate a metabolic switch that is required for the reprogramming of somatic cells to pluripotency, according to Kida et al. in Cell Stem Cell in 2015.

claimAMP-activated protein kinase (AMPK) activation may function as a barrier for reprogramming cells to pluripotency.

referenceProteome dynamics are highly coordinated during the reprogramming of somatic cells to pluripotency, as observed by Hansson et al. in Cell Reports in 2012.

referenceSharma et al. (2013) investigated the role of the SIRT6 protein in the aging and reprogramming of human induced pluripotent stem cells.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 4 facts

claimDefined factors can induce the reprogramming of gastrointestinal cancer cells, as reported by Miyoshi et al. in the Proceedings of the National Academy of Sciences (2010).

referenceGobel et al. (2018) report that interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells, as published in Scientific Reports.

claimAlle et al. (2021) identify emerging strategies for reprogramming that aim to rejuvenate aging cells and tissues.

claimMahmoudi et al. found that heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing, as reported in Nature in 2019.