concept

regulatory T cell

Also known as: Treg, suppressor T cells, regulatory T cell, regulatory T-cells, regulatory CD4(+) T cells

Facts (15)

Sources

Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu Linus Pauling Institute 5 facts

claimVitamin D is suggested to have utility in preventing and treating autoimmune diseases and graft rejections because Th2 cells and regulatory T cells are important regulators in these conditions.

claim1,25-dihydroxyvitamin D3 inhibits the development and function of Th1 cells, but enhances the development and function of Th2 cells and regulatory T cells.

referenceGregori S, Giarratana N, Smiroldo S, Uskokovic M, and Adorini L published 'A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice' in Diabetes in 2002 (volume 51, issue 5, pages 1367-1374), reporting that a 1alpha,25-dihydroxyvitamin D(3) analog increases regulatory T-cells and arrests autoimmune diabetes in NOD mice.

referenceBarrat FJ, Cua DJ, Boonstra A, et al. published 'In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines' in The Journal of Experimental Medicine in 2002 (volume 195, issue 5, pages 603-616), discussing the generation of IL-10-producing regulatory CD4(+) T cells.

claimRegulatory T cells, sometimes called suppressor T cells, function to suppress immune responses.

The immune system and primary immunodeficiency primaryimmune.org Immune Deficiency Foundation 4 facts

claimThe absence of regulatory T cells creates the potential for the body to overreact to an infection, as the immune system would continue working after the infection has been treated.

claimRegulatory T cells function as the thermostat of the lymphocyte system to regulate the immune response.

claimRegulatory T cells suppress or turn off T cells when an infection is controlled and no longer requires an immune response.

claimT cells are categorized into killer (cytotoxic) T cells (CD8 T cells), helper T cells (CD4 T cells), and regulatory T cells, each with distinct roles in the immune system.

Parts of the Immune System | Children's Hospital of Philadelphia chop.edu Children's Hospital of Philadelphia 2 facts

claimRegulatory T cells signal for increased immune activity early in an infection and signal for a decrease in the response as the infection is brought under control.

claimRegulatory T cells manage the immune response by signaling for increased activity early in an infection and signaling for a decrease in the response as the infection is brought under control.

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com Thermo Fisher Scientific 2 facts

claimRegulatory T cells secrete IL-10, a regulatory cytokine that inhibits excessive T cell responses and balances the immune response.

claimRegulatory T cells (Treg), defined as CD4+, CD25+, and Foxp3+ cells, are recruited to sites of infection to mediate immune regulation and control cellular immune responses to viral infections.

3. The Innate Immune System - Immunopaedia immunopaedia.org.za Immunopaedia 1 fact

claimActivated dendritic cells produce IL-12 family cytokines (IL-12, IL-23, and IL-27) which have Th1-cell polarizing capacity, as well as IL-6, IL-10, and TGF-β which have regulatory T cell polarizing effects.

Medicinal plants and human health: a comprehensive review of ... link.springer.com Springer Nov 5, 2025 1 fact

claimAstragaloside IV enhances Th1 cytokine production and diminishes Th2 cytokines while further enhancing the formation of regulatory T-cells (Tregs).