concept

rapamycin

Also known as: rapamycin therapy

Facts (13)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 9 facts

claimLong-term (1 year) rapamycin treatment increases memory and learning in both young and old mice, and improves some of these traits in young animals, suggesting that rapamycin has age-independent beneficial effects.

referenceRapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence.

claimRapamycin rescues age-related changes in muscle-derived stem/progenitor cells from progeroid mice, according to a 2019 study in Molecular Therapy: Methods & Clinical Development.

claimIn the Zmpste24-/- progeria mouse model, rapamycin-treated primary muscle stem cells (MuSCs) restore differentiation and proliferation potential and reverse senescence.

claimRapamycin rescues adult epithelial stem cell (EpSC) exhaustion and the resulting progressive hair loss in mice.

claimRapamycin extends murine lifespan but has limited effects on aging, as reported in a 2013 study in the Journal of Clinical Investigation.

claimRapamycin suppresses mTORC1, which slows the aging of mouse long-term stem cells (LT-HSCs) by maintaining their ability to self-renew and produce blood cells.

perspectiveIt remains debated whether rapamycin is a rejuvenating compound, despite its well-established effects on lifespan.

claimRapamycin improves the function of muscle stem cells (MuSCs) through the induction of autophagy in the Ercc1-/Δ progeria mouse model.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 3 facts

referenceA systematic review by Lee et al. in The Lancet Healthy Longevity (2024) evaluates the targeting of aging in humans using rapamycin and its derivatives.

referenceHam, D.J., Börsch, A., Chojnowska, K., Lin, S., Leuchtmann, A.B., Ham, A.S., et al. (2022) investigated the distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle, published in Nature Communications.

referenceBoada, C., Zinger, A., Tsao, C., Zhao, P., Martinez, J.O., Hartman, K., et al. (2020) demonstrated that rapamycin-loaded biomimetic nanoparticles reverse vascular inflammation, published in Circulation Research.

The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org Frontiers in Psychiatry 1 fact

claimResearch into strategies to maintain or augment the antidepressant response to ketamine has yielded disappointing results for drugs including clonidine, D-cycloserine, lamotrigine, lithium, rapamycin, rapamycin, and riluzole.