concept

psychedelic compounds

Also known as: psychedelic compound

Facts (14)

Sources

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 4 facts

claimThe effects of psychedelic compounds on brain physiology depend on ontogeny, gender, dose, and chemical interactions, as supported by research from Liu et al. (2006), Riga et al. (2016), Skaper and Di Marzo (2012), Lee et al. (2014), Realini et al. (2011), Rubino et al. (2008), Fortunato et al. (2009), Maeda et al. (2007), Marinova et al. (2017), Canales and Ferrer-Donato (2014), and Zuo et al. (2018).

claimThe safe use of psychedelic compounds requires a deeper understanding of their mechanisms because these compounds typically target multiple neurotransmitter systems and can cause undesired effects, as noted by Belouin and Henningfield (2018), Brunton et al. (2011), and Geyer et al. (2009).

claimPsychedelic compounds, including phenethylamines, tryptamines, and cannabinoids, are considered therapeutic options for neuropsychiatric disorders, with reports linking them to increased adult neurogenesis.

claimThe authors of the review focused on the effects of psychedelic compounds on plasticity associated with neurogenesis in the dentate gyrus, rather than the subventricular zone-olfactory bulb (SVZ-OB) system, citing Christie and Cameron (2006) and Kempermann (2012).

Neuroimaging in psychedelic drug development: past, present, and ... nature.com Nature Sep 27, 2023 2 facts

claimPET occupancy studies, when combined with concentration-occupancy relationship data, allow for like-for-like comparisons between different psychedelic compounds.

claimHuman studies are required for a full assessment of psychedelic compounds because of the limitations of animal models.

History and Current Status of Psychedelics and Entactogens ... - NCBI ncbi.nlm.nih.gov Stroud C, Posey Norris SM, Matney C · National Academies Press 2 facts

claimTo ensure safe dosing, psychedelic compounds should not be taken alone, but with a facilitator or therapist who can optimize the patient’s safety.

claimSetting refers to the physical, social, and cultural environment in which psychedelic compounds are taken.

The Role of Psychedelics in Contemporary Psychological ... - PMC pmc.ncbi.nlm.nih.gov PMC Sep 28, 2025 1 fact

claimPsychedelic compounds are currently receiving increased attention across various academic and professional disciplines due to their significant psychological and neurobiological effects.

Psychedelics, Sociality, and Human Evolution frontiersin.org Frontiers 1 fact

referencePokorny et al. (2017) published 'Effect of psilocybin on empathy and moral decision-making' in the International Journal of Neuropsychopharmacology, investigating the impact of the psychedelic compound psilocybin on social cognition.

Psychedelic Drugs News - ScienceDaily sciencedaily.com ScienceDaily 1 fact

claimResearchers have created modified versions of psilocin, the active form of psilocybin, to harness the medical promise of psychedelic compounds while avoiding mind-bending side effects.

DARK Classics in Chemical Neuroscience: NBOMes pubs.acs.org ACS Publications Oct 28, 2019 1 fact

claimN-Benzylphenethylamines, commonly known as NBOMes, are synthetic psychedelic compounds.

Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org Johns Hopkins Center for Psychedelic and Consciousness Research 1 fact

referenceResearchers J. and Carhart-Harris published a study in The British Journal of Psychiatry in 2015 investigating whether psychedelic compounds can play a role in drug dependence therapy.

A Brief Historical Overview of Psychedelic Research - ScienceDirect sciencedirect.com ScienceDirect 1 fact

claimResearch examining psychedelic compounds has experienced a complex and turbulent evolution.