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proteostasis network
Also known as: proteostasis network, proteostasis, proteostasis maintenance mechanisms
Facts (8)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 6 facts
claim4-Phenylbutyric Acid (4-PBA) elevates proteostasis ability in the face of misfolding-induced stress by activating the heat shock response (HSR) and the UPRmt pathway.
referenceThe relationship between proteostasis, oxidative stress, and aging is reviewed in the 2017 paper 'Proteostasis, oxidative stress and aging' published in Redox Biology.
claimChalcone-based derivatives, including nordihydroguaiaretic acid (NDGA), curcumin, resveratrol, quercetin, and isoliquiritigenin, act as dual-targeting drugs that can target both amyloid aggregations and the proteostasis network in vivo.
referenceProteostasis is impaired during skeletal muscle aging, as reported in the 2019 paper 'Impaired proteostasis during skeletal muscle aging' published in Free Radical Biology and Medicine.
referenceLipid assemblies are at the intersection of aging, proteostasis, and neurodegeneration, as described in the 2019 paper 'Lipid assemblies at the crossroads of aging, proteostasis, and neurodegeneration' published in Trends in Cell Biology.
claimKolb et al. (2015) investigated the therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis.
A unified framework for evolutionary genetic and physiological ... journals.plos.org Feb 27, 2024 1 fact
referenceLabbadia J and Morimoto RI published 'The Biology of Proteostasis in Aging and Disease' in the Annual Review of Biochemistry in 2015, detailing the role of proteostasis in the aging process and associated diseases.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
referenceLee TT, Chen P, Su MP, Li JC, Chang YW, Liu RW, et al. authored 'Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila', published in Aging Cell in 2021 (20:e13379, doi: 10.1111/acel.13379).