Knowledge Tree
prostaglandins
Also known as: prostaglandins E, prostanoids
Facts (21)
Sources
The Normal Menstrual Cycle and the Control of Ovulation - NCBI - NIH ncbi.nlm.nih.gov Aug 5, 2018 11 facts
claimIn response to luteinizing hormone (LH) and progesterone, prostaglandins and proteolytic enzymes (such as collagenase and plasmin) increase and digest collagen in the follicular wall, leading to the release of the oocyte-cumulus complex.
claimThe release of prostaglandins during menstruation may be caused by decreased stability of lysosomal membranes in endometrial cells.
claimProstaglandins may stimulate ovum release by stimulating smooth muscle within the ovary.
referenceEspey L.L. et al. published a study in 1991 in the American Journal of Physiology comparing ovarian hydroxyeicosatetraenoic acids with prostanoids and steroids during ovulation in rats.
claimThe release of prostaglandins during menstruation may be caused by decreased stability of lysosomal membranes in endometrial cells.
claimTissue ischemia in the superficial endometrial layers (the spongiosa and compacta) occurs due to decreased blood flow, leading to the release of prostaglandins that cause uterine smooth muscle contractions and the sloughing of degraded endometrial tissue.
claimProstaglandins may stimulate proteolytic enzymes, while hydroxyeicosatetraenoic acids (HETEs) may stimulate angiogenesis and hyperemia.
claimProstaglandins and proteolytic enzymes, such as collagenase and plasmin, increase in response to luteinizing hormone (LH) and progesterone, leading to the digestion of collagen in the follicular wall and the release of the oocyte-cumulus complex.
claimIf pregnancy does not occur, the corpus luteum undergoes luteolysis under the influence of estradiol and prostaglandins and forms scar tissue called the corpus albicans.
measurementConcentrations of prostaglandins E and F series and hydroxyeicosatetraenoic acid (HETE) reach peak levels in follicular fluid just prior to ovulation.
claimIf pregnancy does not occur, the corpus luteum undergoes luteolysis under the influence of estradiol and prostaglandins, forming scar tissue known as the corpus albicans.
Menstrual Cycle Phases: Decoding the Stages - Perelel perelelhealth.com Oct 22, 2024 2 facts
claimProstaglandins are hormone-like lipids that assist the uterus in shedding its lining by helping muscles relax, which can lead to cramping and digestive changes during the menstrual phase.
claimDuring the transition to the menstrual phase, prostaglandins cause the uterus to contract, leading to cramps and bleeding, which marks Day 1 of the next cycle.
Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 1 fact
referenceNonsteroidal anti-inflammatory agents affect sleep by decreasing the production of sleep-promoting prostaglandins, suppressing the normal surge of melatonin, and altering the daily rhythm of body temperature (Murphy et al., 1994, 1996).
Understanding the Phases of the Menstrual Cycle - Clue helloclue.com 1 fact
claimIn the late secretory phase, the body produces prostaglandins, which are hormone-like compounds that can cause cramps to help shed the uterine lining if pregnancy does not occur.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 1 fact
claimLinalool and eugenol found in Ocimum basilicum Linn. exhibit analgesic activity by inducing inhibition of cyclo-oxygenase activity and inhibiting pain mediator biosynthesis, including prostaglandins, prostacyclin, and opioid receptor interactions, according to Govindarajan et al.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimVitamin D exerts anti-inflammatory activity by suppressing inflammatory mediators such as prostaglandins and nuclear factor kappa-light-chain-enhancer of activated B cells.
Wound Inflammation lakecountyin.gov 1 fact
claimPro-inflammatory mediators such as prostaglandins and leukotrienes contribute to the symptoms of redness, heat, swelling, and pain during the inflammatory response.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
claimDuring an inflammatory response, long-chain polyunsaturated fatty acids (such as arachidonic acid and eicosapentaenoic acid) in immune cell membranes are metabolized by enzymes into eicosanoids, including prostaglandins, leukotrienes, and thromboxanes, which have varying effects on inflammation.
Understanding the Inflammatory and Healing Process - Myo-Fit myofittherapy.com Nov 12, 2024 1 fact
procedureThe initial phase of the inflammatory process involves the release of inflammatory mediators, such as histamines, cytokines, and prostaglandins, in response to trauma, overuse, or surgery.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
claimApigenin demonstrates dual inhibitory effects on COX-2 and 5-lipoxygenase, obstructing the synthesis of prostaglandins and leukotrienes (Sen et al. 2021).