Knowledge Tree
propofol
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A Synergistic Workspace for Human Consciousness Revealed by ... elifesciences.org 12 facts
procedureThe network-based statistic approach is a nonparametric statistical method used to investigate the statistical significance of propofol-induced or DOC-induced alterations in graph data, designed to control the family-wise error due to multiple comparisons.
measurementDuring the study 'A Synergistic Workspace for Human Consciousness Revealed by...', the mean estimated effect-site propofol concentration was 2.48 µg mL-1 (range 1.82-3.14 µg mL-1) and the mean estimated plasma propofol concentration was 2.68 µg mL-1 (range 1.92-3.44 µg mL-1) at Ramsay level 5.
procedurePropofol administration in the study 'A Synergistic Workspace for Human Consciousness Revealed by...' utilized an AS50 auto syringe infusion pump (Baxter Healthcare, Singapore) and the TIVA Trainer (European Society for Intravenous Anaesthesia) pharmacokinetic simulation program to achieve target-controlled infusion.
referenceThe TIVA Trainer pharmacokinetic simulation program used in the study 'A Synergistic Workspace for Human Consciousness Revealed by...' followed the Marsh 3-compartment model to specify blood concentrations of propofol for target-controlled infusion.
measurementThe mean total mass of propofol administered to participants in the study was 486.58 mg, with a range of 373.30 mg to 599.86 mg.
procedureThe study 'A Synergistic Workspace for Human Consciousness Revealed by...' acquired resting-state fMRI data at two propofol levels: no sedation (Awake) and Deep anaesthesia (Ramsay score of 5).
measurementThe propofol data used in the study were collected between May and November 2014 at the Robarts Research Institute in London, Ontario.
claimPropofol disrupts the processing of thalamocortical sensory information, a phenomenon termed 'thalamocortical isolation', as evidenced by both resting-state integration of information between brain regions and stimulus-evoked responses within each region.
claimFollowing the discontinuation of propofol, participants reached level 2 of the Ramsay scale approximately 11 minutes later, characterized by clear and rapid responses to verbal commands, which the researchers defined as the 'recovery' period.
referenceThe study 'Brain imaging reveals covert consciousness during behavioral unresponsiveness induced by propofol' published in Scientific Reports demonstrates that brain imaging can detect covert consciousness in patients who are behaviorally unresponsive due to propofol.
claimPropofol-induced saturation of EEG slow-wave activity (SWAS) causes thalamic, auditory, and somatomotor brain regions to stop responding to sensory stimuli.
referenceThe study 'Consciousness and complexity during unresponsiveness induced by propofol, xenon, and ketamine' published in Current Biology examines consciousness and complexity in states of unresponsiveness induced by propofol, xenon, and ketamine.
Classification Schemes of Altered States of Consciousness - ORBi orbi.uliege.be 1 fact
referenceMonti, Lutkenhoff, Rubinov, Boveroux, Vanhaudenhuyse, Gosseries, Bruno, Noirhomme, Boly, and Laureys investigated the dynamic change of global and local information processing during propofol-induced loss and recovery of consciousness in a 2013 study published in PLOS Computational Biology.
Protocol for testing global neuronal workspace and integrated ... journals.plos.org 1 fact
procedureSurgical procedures for brain recording access involve a head post surgery for head stabilization and a craniotomy for probe insertion, performed under general anesthesia using either isoflurane gas (1–3% isoflurane/O2) for mice and NHPs, or constant rate infusion of propofol (0.1–0.6 mg/kg/min, IV) for NHPs only.
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 1 fact
referenceVarley et al. investigated the differential effects of propofol and ketamine on critical brain dynamics, published in PLOS Computational Biology in 2020.