Knowledge Tree
progenitor cells
Also known as: progenitors
Facts (15)
Sources
Rusty Gage, PhD - Salk Institute salk.edu 5 facts
referenceIn the 2002 study 'The adult substantia nigra contains progenitor cells with neurogenic potential' published in the Journal of Neuroscience, Lie et al. demonstrate that the adult substantia nigra contains progenitor cells capable of neurogenesis.
referenceI.L. Weissman, D.J. Anderson, and Rusty Gage published 'Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations' in the Annual Review of Cell and Developmental Biology in 2001.
claimFibroblast growth factor-2 (FGF-2) is sufficient to isolate progenitor cells found in the adult mammalian spinal cord, according to Shihabuddin, Ray, and Gage in 1997.
referenceP.J. Horner, A.E. Power, Gerd Kempermann, H.G. Kuhn, T.D. Palmer, J. Winkler, L.J. Thal, and Rusty Gage published 'Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord' in the Journal of Neuroscience in 2000.
referenceT.D. Palmer, P.H. Schwartz, P. Taupin, B. Kaspar, S.A. Stein, and Rusty Gage published 'Cell culture. Progenitor cells from human brain after death' in Nature in 2001.
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 3 facts
claimAdult tissue-specific stem and progenitor cells utilize defensive mechanisms to reduce endogenous DNA damage, thereby maintaining genomic integrity and tissue homeostasis.
claimExpression of OSKM specifically in hepatocytes dedifferentiates adult hepatocytes into progenitor cells and promotes cell proliferation, increasing liver plasticity and regeneration.
claimRasouli M., Rahimi A., Soleimani M., and Keshel S. H. analyzed the interplay between the extracellular matrix and progenitor/stem cells during wound healing in a 2021 study published in Acta Histochemica.
Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org 1 fact
claimIn ad libitum-fed mice, intestinal stem cells, but not progenitors, are the cell of origin for intestinal adenomas and adenocarcinomas.
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Dec 19, 2024 1 fact
claimIn the context of the review, neurogenesis is defined as the process of generating new neurons through cell division, which includes proliferation (multiplication of neural stem or progenitor cells), differentiation (commitment of cells into specific neuronal lineages), migration (movement to designated locations), maturation (development of dendrites, axons, and synaptic capabilities), integration (incorporation into existing neural networks), and survival (persistence of these neurons within the neural circuitry).
Chronic inflammation in the etiology of disease across the life span nature.com Dec 5, 2019 1 fact
claimMaternal inflammation contributes to brain overgrowth and autism-associated behaviors in offspring through altered redox signaling in stem and progenitor cells, according to a 2014 study by Le Belle et al.
From Homeostasis to Allodynamic Regulation (Chapter 18) cambridge.org 1 fact
claimProgenitor cells are mobilized by acute psychological stress but not by beta-adrenergic receptor agonist infusion.
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 1 fact
referenceTsatmali et al. (2005) observed that newborn neurons acquire high levels of reactive oxygen species and increased mitochondrial proteins upon differentiation from progenitor cells.
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 1 fact
claimMast cells develop from bone marrow-derived progenitor cells that are primed with stem cell factor (SCF) and continue maturation and differentiation in peripheral tissue.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
referenceThe article 'Extracellular vesicles from stem and progenitor cells for cell-free regenerative therapy' was published in Current Molecular Medicine in 2022 (Volume 22, pages 120–31).