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potassium channels
Also known as: potassium channel, K channels
Facts (11)
Sources
A Hilbertian approach to biological problems | PLOS Complex ... journals.plos.org Nov 5, 2024 5 facts
claimThe speed at which a change of functional space occurs in potassium channels is controlled by the duration of prior inactivation.
claimExtracellular acidity impacts cytosolic pH, which alters the opening probability and activation of potassium channels like KcsA, causing a departure from the energetically favored closed state and placing an energy demand on the cell.
claimEarly ion channels, such as calcium channels, evolved to include potassium and sodium ions, eventually becoming dedicated potassium and sodium channels to improve the precision and speed of signaling.
referenceDoyle DA, Cabral JM, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, et al. published 'The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity' in Science in 1998, establishing the structural basis for how potassium channels conduct ions and maintain selectivity.
claimNeurons exhibit differential expression of sodium (Na) and potassium (K) channels between the soma and dendrites, which contributes to setting the functional landscape of cellular functioning.
Neuroanatomy, Neuron Action Potential - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
claimParalytic shellfish toxins (PSTs) are found in marine and freshwater environments among dinoflagellates and function by binding to and blocking voltage-gated sodium channels, while also targeting potassium and calcium channels to some degree.
claimThe relative refractory period follows the absolute refractory period, during which a neuron may only generate an action potential if a much higher threshold is reached, because some sodium channels are ready to open while many remain inactivated and some potassium channels remain open.
claimThe absolute refractory period is the state immediately following the generation of an action potential during which a neuron cannot generate another action potential because sodium channels are inactivated and closed while potassium channels remain open.
Peer-Reviewed Papers - The Levin Lab drmichaellevin.org 2 facts
referenceAdams, D. S., Uzel, S. G. M., Akagi, J., Wlodkowic, D., Andreeva, V., Yelick, P. C., Devitt-Lee, A., Paré, J-F., and Levin, M. published 'Bioelectric signaling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome' in the Journal of Physiology, volume 594, issue 12, pages 3245-3270, in 2016.
referencePayne et al. published 'Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer' in EBioMedicine in 2022, establishing that potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer.
Bioelectricity - The Levin Lab drmichaellevin.org 1 fact
claimModulation of potassium channels confers a hyperproliferative invasive phenotype on embryonic stem cells, according to a 2008 study by Morokuma, Blackiston, Adams, Seebohm, Trimmer, and Levin published in the Proceedings of the National Academy of Sciences.