Knowledge Tree
Polyphenolic compounds
Also known as: Polyphenolic compounds, Polyphenolic substances
Facts (13)
Sources
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 12 facts
claimPolyphenolic compounds demonstrate structure–activity correlations where the placement of hydroxyl groups and conjugation patterns dictate radical scavenging efficacy.
claimPolyphenolic substances suppress lanosterol 14α-demethylase through competitive binding to the enzyme's active site, which obstructs the transformation of lanosterol into ergosterol, the primary sterol constituent of fungal membranes.
referenceChociej P, Foss K, Jabłońska M, Ustarbowska M, and Sawicki T (2024) analyzed the profile and content of polyphenolic compounds, as well as the antioxidant and anti-glycation properties, of root extracts from selected medicinal herbs.
claimPolyphenolic substances prevent atherosclerosis by impeding LDL oxidation, averting scavenger receptor activation, and promoting cholesterol export from macrophages.
referenceSantos et al. (2021) predicted the antioxidant effects of polyphenolic compounds and their structure-activity relationships using multivariate regression trees.
claimThe approach of using polyphenolic substances to target critical stages in foam cell development offers complete atherosclerosis prevention that surpasses single-target therapies according to Nijat et al. (2025).
claimPolyphenolic substances, specifically catechins and their gallate esters, possess antifungal properties by inhibiting lanosterol 14α-demethylase, which is an essential enzyme in ergosterol biosynthesis.
claimThe inhibition of lanosterol 14α-demethylase by polyphenolic substances undermines fungal cell membrane integrity and jeopardizes cellular homeostasis.
procedureThe procedure for radical scavenging by polyphenolic compounds entails electron donation to neutralize free radicals, with the resultant phenoxyl radicals being stabilized via resonance structures.
claimFungal cell death caused by polyphenolic substances results from membrane instability, which leads to heightened permeability, ion leakage, osmotic stress, and metabolic disturbance.
claimPolyphenolic substances inhibit the uptake of oxidized LDL by macrophages, which diminishes foam cell production and the progression of atherosclerotic plaques.
claimPolyphenolic compounds, specifically resveratrol and EGCG, induce apoptosis in cancer cells by depolarizing the mitochondrial membrane and releasing cytochrome c.
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 1 fact
claimFlavonoids are a subset of polyphenolic compounds that encompass over 9,000 recognized natural molecules.