concept

pluripotency

Also known as: pluripotent potential

Facts (14)

Sources

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 12 facts

claimMitochondrial metabolism and the active TCA cycle are maintained during pluripotency and can be fueled by different sources.

claimRecent studies have investigated the functional and molecular differences between naïve and primed pluripotent stem cell (PSC) states to understand the relevance of mitochondrial metabolism for pluripotency.

referenceFolmes et al. (2011) reported that somatic oxidative bioenergetics transition into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

claimWhile a glycolytic switch is necessary to acquire pluripotency, the early phases of induced pluripotent stem cell (iPSC) generation are characterized by an initial increase in oxidative phosphorylation (OXPHOS) activity and the up-regulation of respiratory chain (RC) complexes.

claimGlobal DNA hypomethylation is a feature of pluripotent stem cells (PSCs) required during cellular reprogramming to establish pluripotency.

referenceJang et al. (2012) reported that O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network.

referenceERRs mediate a metabolic switch that is required for the reprogramming of somatic cells to pluripotency, according to Kida et al. in Cell Stem Cell in 2015.

claimThe role of mitochondrial activity in pluripotency may be independent of glycolytic regulation.

referenceVazquez-Martin et al. (2012) observed that mitochondrial fusion induced by pharmacological manipulation impedes somatic cell reprogramming to pluripotency.

claimAMP-activated protein kinase (AMPK) activation may function as a barrier for reprogramming cells to pluripotency.

referenceProteome dynamics are highly coordinated during the reprogramming of somatic cells to pluripotency, as observed by Hansson et al. in Cell Reports in 2012.

referenceCarey BW et al. demonstrated in 2014 that intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells.

Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org Genes & Development 1 fact

claimMaintenance of increased total alpha-ketoglutarate (αKG):succinate pools maintains pluripotency in mouse embryonic stem cells.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 1 fact

claimTriboelectric stimulation boosts the pluripotency and differentiation potential of old bone marrow-derived mesenchymal stem cells (BMSCs), enhances their proliferation, and reverses senescence phenotypes through MDM2-dependent p53 degradation.