concept

PI3K/AKT/mTOR signaling pathway

Also known as: PI3K/AKT/mTOR pathways, PI3K/Akt pathway, PI3K/AKT/mTOR signaling pathway, PI3K/Akt/mTOR pathway

Facts (5)

Sources

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 4 facts

referenceL. Yu, J. Wei, and P. Liu published 'Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer' in Seminars in Cancer Biology in 2022, focusing on therapeutic strategies targeting the PI3K/Akt/mTOR pathway in cancer.

referenceD. Tewari, P. Patni, A. Bishayee, A. Sah, and A. Bishayee published 'Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy' in Seminars in Cancer Biology in 2022, discussing natural products as therapeutic agents targeting the PI3K-Akt-mTOR pathway.

referenceM.K. Ediriweera, K.H. Tennekoon, and S.R. Samarakoon published 'Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance' in Seminars in Cancer Biology in 2019, detailing the significance of the PI3K/AKT/mTOR pathway in ovarian cancer.

referenceA. Glaviano, A. Foo, S.C. Lam, H.Y. Yap, K.C.H. Yap, W. Jacot, R.H. Jones, et al. published 'PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer' in Molecular Cancer in 2023, reviewing the PI3K/AKT/mTOR signaling pathway and its role in cancer therapy.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 1 fact

claimThe interaction between the NFE2L2, PGC-1, p62, AMPK, and PI3K/Akt/mTOR pathways is considered important for autophagy-based rejuvenative strategies in age-related macular degeneration (AMD).