concept

phencyclidine

Also known as: PCP

Facts (14)

Sources

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 13 facts

claimClozapine prevents a decrease in neurogenesis in mice that have been repeatedly treated with phencyclidine.

measurementIn studies of phencyclidine (PCP) exposure, all research employed physiological assessments, and approximately 50% included behavioral evaluation tests.

accountA study by Liu et al. (2006) found that acute and 5-day chronic exposure to 7.5 mg/kg of phencyclidine (PCP) resulted in minor or no effects on cell proliferation, differentiation, and survival in the dentate gyrus of adult rats compared to saline controls.

referenceJavitt and Zukin (1991) reviewed recent advances in the phencyclidine (PCP) model of schizophrenia.

referenceLiu J et al. investigated the effects of repeated phencyclidine (PCP) administration on adult hippocampal neurogenesis in rats.

claimPrenatal exposure to phencyclidine alters hippocampal cell proliferation in offspring rats, according to a 2009 study by Tanimura et al. published in Synapse.

claimMost studies investigating phencyclidine (PCP) have focused on determining the neurocognitive damage resulting from chronic exposure during in utero or neonatal development.

accountIn the study by Liu et al. (2006), decreases in cell proliferation induced by phencyclidine (PCP) treatments were restored to control levels after one week of abstinence.

claimThe study by Liu et al. (2006) on phencyclidine (PCP) exposure lacks detailed information on the exact age of the animals, which is a factor that strongly influences adult neurogenesis.

claimKetamine and phencyclidine (PCP) were initially employed as anaesthetics in the late 20th century.

claimKetamine and phencyclidine (PCP) are synthetic drugs originally discovered at the Parke-Davis Research Center and are among the most studied NMDA antagonists.

claimEarly exposure to phencyclidine (PCP) has a significantly detrimental impact on neurogenesis and overall plasticity.

measurementBrdU labelling was the most frequently used method in studies of phencyclidine (PCP) exposure, accounting for 80% of the studies.

Overview of Anxiety Disorders - Psychiatry - MSD Manuals msdmanuals.com MSD Manuals 1 fact

claimCannabis (marijuana) can induce anxiety in some individuals, either directly or through adulterants such as phencyclidine (PCP).