Knowledge Tree
perturbation
Also known as: perturbation, perturbations
Facts (16)
Sources
Allostasis revisited: A perception, variation, and risk framework frontiersin.org Sep 28, 2022 10 facts
claimThe reliability of internal cues as indicators of survival threat varies, and errors in decisions responding to these cues are more likely when the perturbation is novel or the climate has changed.
claimPhysiological responses to environmental changes include predictive changes (such as seasons) and facultative responses to perturbations, which can be severe and occur at any time.
referenceWingfield et al. (1998) and Angelier and Wingfield (2013) highlight that neural integration is critical in determining behavioral outcomes in response to perturbations, as glucocorticoid exposure can lead to variable outcomes depending on species, individuals, and circumstances.
claimAnimals use the glucocorticoid signal as one of many cues to determine appropriate behavioral outcomes in response to perturbations.
claimResource-related cues indicate the temporal outlook of a perturbation, specifically whether it will end and when. These cues are reliable when the perturbation is short-lived or has been experienced before, but they are less reliable when the perturbation is novel or the climate has changed.
claimThe role of glucocorticoids in the 'take it or leave it' decision in response to perturbations is well-documented, but the variability in outcomes based on species, individuals, circumstances, and hormone exposure highlights the importance of neural integration.
claimHormonal cascades, specifically the hypothalamo-pituitary-adrenal cortex (HPA) axis, play a key role in vertebrate responses to perturbations.
claimElevated glucocorticoid levels indicate a perception of perturbation and systemic activation of the Emergency Life History Stage (ELHS).
claimThe reliability of internal cues as accurate indicators of threat to survival varies based on factors such as individual responsiveness, the duration of the perturbation, and the novelty of the perturbation.
claimResource-related cues indicate the temporal outlook of a perturbation, specifically whether the perturbation will end and when.
Homeostasis and Health: From Balance to Change | Biological Theory link.springer.com Oct 14, 2025 4 facts
claimThe cybernetic interpretation of homeostasis characterizes the environment primarily as a source of perturbations that an organism must block or compensate for, which limits the understanding of health in relation to the environment.
claimBy applying the cybernetic model to biological homeostasis, scientists associate biological regulation with compensation for perturbations, aiming to return the system to an initial or stable state defined by a setpoint.
perspectiveThe authors of the article advocate for a shift in the perspective on health from one based on stability to one focused on the capability for change, arguing that biological systems often respond to perturbations by changing themselves rather than returning to an initial or normal state.
claimThe cybernetic view of homeostasis presupposes that a system is stable when unperturbed and only activates in reaction to perturbations to restore the original state.
A virtual clinical trial of psychedelics to treat patients with disorders ... eurekalert.org Nov 24, 2025 1 fact
claimThe simulation of LSD and psilocybin on patients with disorders of consciousness boosted the patients' responses to perturbations.
Psychedelics Assessed In New Virtual Clinical Trial - EMJ emjreviews.com Nov 27, 2025 1 fact
claimThe virtual clinical trial method was validated by demonstrating that responses to perturbations were lower in states of reduced consciousness, such as in patients with disorders of consciousness and healthy people under anaesthesia, compared with normal waking states.