concept

Paradigm of Allostatic Organization

Also known as: Allostatic, PAO, Predictive Adaptive Response

Facts (18)

Sources

A Copernican Approach to Brain Advancement: The Paradigm of ... frontiersin.org Frontiers in Human Neuroscience Apr 25, 2019 18 facts

claimHomeostatic evidence regarding the effects of subtle yet chronic stress is inadequate for the conceptualizations required by the PAO (Paradigm of Allostatic Organization).

perspectiveThe PAO aims to inspire new forms of allostatic thinking, research, and action, including new attention toward currently under-attended classes of biological phenomena, as an evolutionary approach to brain advancement.

claimThe PAO (Paradigm of Allostatic Organization) construct of the allostatic state represents the integrated totality of brain-body interactions and optimal anticipatory oscillation, which is potentially a function of the mathematically-defined state of criticality.

claimThe necessity of 'Sterling allostasis' (or the PAO) arises because current biological data collection and causal inference methodologies systematically limit or ignore parameter variability influenced by complex environments and neural complexity, such as top-down efficacy for regulation of whole-body physiology.

claimInterventional strategies within the Predictive Adaptive Response (PAO) framework are not limited to social or political factors but can also include modifications to the built environment.

claimThe 'PAO' (Paradigm of Allostatic Organization) framework suggests research into 'Allostatic intervention for critical brain dynamics in diabetics results in tighter glucose control without increasing episodes of hypoglycemia,' which focuses on promoting agility for variation in allostatic states and neurally-directed orchestrations of hormone levels.

perspectiveThe Paradigm of Allostatic Organization (PAO) rejects the naturalistic fallacy, asserting that no understanding of physical law can force the making of a particular human choice.

claimThe Paradigm of Allostatic Organization (PAO) aligns with the philosophy of freedom, and Bettinger (2017) suggests that the subjective feeling of freedom of choice may be the experiential dimension of the objectively defined state of criticality.

claimThe Paradigm of Allostatic Organization (PAO) promotes self-creativity, non-obsolescence, empowerment, and citizenship as conceptual 'upgrades' to the traditional bioethical principles of autonomy, non-maleficence, beneficence, and justice.

perspectiveThe PAO (Predictive Adaptive Response/Allostatic) perspective aims to advance the science of brain advancement by facilitating a wider range of choices, possibilities, and uses of the imagination.

claimThe 'PAO' (Paradigm of Allostatic Organization) framework suggests potential research topics such as 'Stratification in frequency domain analysis of ecologically monitored glucose allostasis identifies new potential risk factors for pre-diabetes,' which focuses on the context-dependence of physiological variability and oscillatory properties of parameter estimates for early disease prevention.

perspectiveThe PAO perspective argues that the clinical construct of Posttraumatic Stress Disorder (PTSD) is not a tenable method for distinguishing between 'healthy' and 'diseased' individuals.

claimThe Predictive Adaptive Response (PAO) definition of health, which views health as an active state of anticipatory behaviors relative to a changing environment, contradicts the homeostatic view that there is a single, objectively "normal" biological state.

referenceThe Paradigm of Allostatic Organization (PAO) aligns with principles of advanced neuroethics for self-transformative technologies, as articulated by Shook and Giordano (2016).

claimThe 'PAO' (Paradigm of Allostatic Organization) framework suggests research into 'Alteration in pre-prandial glucose allostasis through a comprehensive lifestyle intervention,' which emphasizes anticipatory regulation and whole-person behavior.

claimThe Paradigm of Allostatic Organization (PAO) includes engagement with questions regarding the nature of the 'good life' because allostasis recognizes the importance of the brain and the human neocortex's role in higher-order information processing, including ethical considerations.

claimIntervening on a mediator of top-down neural effects does not automatically constitute "allostatic therapy," as the Sterling principle of allostasis and the PAO focus instead on the brain's unique, changing dynamics and its association with whole-organism behaviors in context.

claimThe Paradigm of Allostatic Organization (PAO) suggests that mental training, physical exercise, yoga, and related strategies can support the attenuation of elevated set points for the human stress response system, as supported by Streeter et al. (2012) and Pau et al. (2016).