Knowledge Tree
Paradigm of Allostasis
Also known as: PAO, Paradigm of Allostasis, Paradigm of Allostatic Orchestration
Facts (28)
Sources
A Copernican Approach to Brain Advancement: The Paradigm of ... frontiersin.org Apr 25, 2019 26 facts
claimHomeostasis emerged from 19th-century physico-chemical insights applied to life processes, while the Paradigm of Allostatic Orchestration emerged from naturalistic observations, post-Darwinian evolutionary perspectives, and the brain's role as a prediction machine.
claimThe homeostasis paradigm utilizes linear models, whereas the Paradigm of Allostatic Orchestration utilizes models based on complexity, criticality, and non-linear dynamics.
perspectiveThe Paradigm of Allostasis (PAO) does not advocate for a return to vitalistic reasoning, viewing disease as punishment, or using the methods of Mesmer.
claimThe paradigm of allostatic orchestration (PAO) is proposed as a new paradigm that is distinct from the earlier paradigm of corrective feedback regulation.
claimThe homeostasis paradigm defines stability as 'stability through constancy,' whereas the Paradigm of Allostatic Orchestration (PAO) defines stability as 'stability through change,' which resembles constancy when neural and environmental complexities are minimized.
claimHomeostasis research is conducted in controlled laboratory conditions, whereas the Paradigm of Allostatic Orchestration research focuses on open and changing environmental contexts.
claimHomeostasis approaches therapeutics by modifying specific mechanisms deemed dysfunctional, while the Paradigm of Allostatic Orchestration approaches therapeutics by facilitating the brain's endogenous orchestrative capacities and modifying influences from the natural environment.
perspectiveThe Paradigm of Allostasis (PAO) perspective is potentially better suited for large-scale brain advancement objectives involving heterogeneous populations compared to homeostatic approaches.
referenceSung W. Lee published the article 'A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration' in Frontiers in Human Neuroscience on April 26, 2019.
perspectiveThe Paradigm of Allostasis (PAO) acknowledges that incorporating consciousness into scientific research will require advanced forms of conceptualization and engagement to address ethical dilemmas.
claimIn the homeostasis paradigm, the brain is viewed as one organ among others, whereas in the Paradigm of Allostatic Orchestration, the brain is viewed as the central and integrative site of information processing for all organs and behaviors.
claimHomeostasis explains pathology as the production of categorically dysfunctional molecular interactions, whereas the Paradigm of Allostatic Orchestration explains pathology as the persistence of molecular interactions that are not beneficial for a given context, often associated with neurally-directed rigidification of oscillatory patterns.
claimThe homeostasis paradigm views free will as a 'user illusion' resulting from determined molecular processes, whereas the Paradigm of Allostatic Orchestration views free will and consciousness as real phenomena with causal top-down efficacy.
claimThe homeostasis paradigm does not emphasize disease comorbidity due to its focus on system-specific mechanisms, while the Paradigm of Allostatic Orchestration predicts comorbidity due to cross-system effects orchestrated at the level of the brain.
claimThe Paradigm of Allostatic Orchestration considers complexities of top-down neural effects and environmental context as foundational, rather than factors to be excluded, with anticipatory regulation serving as the principle of their interface.
perspectiveThe Paradigm of Allostasis (PAO) argues that neuroscience and healthcare should cease ignoring the significance of subjectivity and consciousness in research and clinical practice.
claimHomeostasis utilizes a 'bottom-up' causal inference model where molecular interactions determine higher-level phenomena, whereas the Paradigm of Allostatic Orchestration utilizes a 'top-down' or bidirectional model where neocortical activity and environmental factors influence lower-level biological phenomena.
claimThe term 'paradigm of allostatic orchestration' (PAO) is used to refer to the original brain-centric and cross-system perspective on allostasis put forth by Peter Sterling, distinguishing it from subsequent usages by other investigators.
claimHomeostasis defines health as the absence of disease, while the Paradigm of Allostatic Orchestration defines health as optimal anticipatory oscillation for complex and changing environments.
claimThe Paradigm of Allostatic Orchestration (PAO) extends the principle of allostasis, defined as 'stability through change,' as originally put forth by Peter Sterling.
claimThe Paradigm of Allostatic Orchestration originates from an evolutionary perspective and recognizes that biological set points change in anticipation of changing environments.
claimHomeostasis derives ethical considerations from Enlightenment-era liberal philosophy, while the Paradigm of Allostatic Orchestration integrates conventional biomedical ethics with neuroethics, including principles like self-creativity, non-obsolescence, empowerment, and citizenship.
claimHomeostasis focuses on genes and molecules with interactions based on corrective feedback, while the Paradigm of Allostatic Orchestration focuses on neural function, environmental context, and mediator pathways with interactions based on anticipatory behavior.
referenceUnder the Predictive Adaptive Organization (PAO) framework, allostasis is defined as the integrated totality of brain-body interactions, irrespective of environmental factors, and the term 'allostatic orchestration' is used as a synonym to highlight top-down neural and cross-system effects.
claimIn the Paradigm of Allostatic Orchestration, the brain acts as the organ of central command, orchestrating cross-system operations to support optimal behavior at the level of the whole organism.
claimHomeostasis views 'normal' biology based on statistical modeling and population averages, whereas the Paradigm of Allostatic Orchestration posits that all biological function is context-sensitive and no context is 'normal' in an absolute sense.
Understanding Allostasis: Stability Through Change - Cannelevate cannelevate.com.au Jan 2, 2026 2 facts
claimThe paradigm of allostatic orchestration, as articulated by Sung Lee, posits that biological set-points change in anticipation of changing environments, with the brain acting as the central command organ for cross-system operations.
perspectiveThe paradigm of allostatic orchestration, articulated by Sung Lee, posits that biological set-points change in anticipation of changing environments.