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optimal anticipatory oscillation
Also known as: PAO, optimal anticipatory oscillations
Facts (16)
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A Copernican Approach to Brain Advancement: The Paradigm of ... frontiersin.org Apr 25, 2019 15 facts
claimOptimal Anticipatory Oscillation (PAO) is defined as the flexible, instantaneous, and iterated orchestration of multiple mechanisms across systems, allowing for dynamic interaction with nature when the brain and environment change at rates faster than intergenerational gene transfer.
claimHealth is hypothesized to be an allostatic state of optimal anticipatory oscillation, which relates to the state of criticality, defined as a mathematical point of poise between phases on the border between order and disorder.
claimThe tendency to maintain a state of criticality, defined as a point of mathematical poise between phases on the border between order and disorder, is hypothesized to explain the likelihood of expressing optimal anticipatory oscillations.
claimOptimal anticipatory oscillation reflects an individual's capacity to match internal operations with the oscillatory features of their environment, thereby reducing limitations, enhancing resilience, and expanding functional opportunities.
claimOptimal anticipatory oscillation affects immunity, as demonstrated in a study by Kox et al. (2014) involving meditation, breath training, and cold temperature exposure, which required the anticipatory tuning of cognitive appraisals and breathing cycles.
referencePeter Sterling defined health as 'optimal predictive fluctuation' in 2004, a concept that serves as a predecessor to optimal anticipatory oscillation and challenges the traditional view of health as merely a capacity for reactive or corrective feedback.
claimOptimal Anticipatory Oscillation (PAO) does not rely on the concepts of adaptation or natural selection.
claimThe concept of optimal anticipatory oscillation is grounded in the neuroscientific perspective of the brain as a 'prediction machine,' as supported by research from Engel et al. (2001) and Buzsaki (2006).
claimThe Optimal Anticipatory Oscillation (PAO) theory posits that the critical state of the brain, or critical states of neuro-analogous structures in organisms without brains, serves as a general vehicle for evolutionary processes.
claimThe concept of optimal anticipatory oscillation (PAO) was introduced as a framework to facilitate new thinking and scientific imagination regarding the operationalization of health.
claimHomeostasis defines health as the absence of disease, while the Paradigm of Allostatic Orchestration defines health as optimal anticipatory oscillation for complex and changing environments.
claimThe PAO framework postulates a spectrum of allostatic states characterized by varying tendencies for optimal anticipatory oscillation: at one end, 'allostatic states of optimality' indicate a dynamic capacity for recalibration associated with positive health; at the other end, 'allostatic states of impairment' indicate rigidification in operational set points and manifest as disease.
claimThe behavioral manifestations of optimal anticipatory oscillation include characteristic sleep patterns (Buysse, 2014), specific motor behaviors or sensory acuity (McClintock et al., 2016), and positive cognitive appraisals (Kalisch et al., 2015).
claimThe relationship between criticality and optimal anticipatory oscillation may be non-linear, as many brain functions likely operate on the basis of power laws, as suggested by Thiel (2014), Bettinger (2017), and Kasagi et al. (2017).
claimIn the cardiovascular system, optimal anticipatory oscillation is demonstrated through heart rate variability patterns that indicate a capacity for rapid recalibrations of cardiac output, which is associated with a decreased risk of morbidity or mortality according to research by Kleiger et al. (1987) and Dekker et al. (1997).
Understanding Allostasis: Stability Through Change - Cannelevate cannelevate.com.au Jan 2, 2026 1 fact
claimHealth is defined as optimal anticipatory oscillation, characterized by dynamic flexibility across systems, whereas disease is defined as impaired anticipatory oscillations with rigidified set-points.