concept

nutrient-sensing signaling network

Also known as: nutrient-sensing pathways, nutrient sensing signaling networks, nutrient sensing, nutrient-sensing network, nutrient-sensing signals

Facts (4)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 3 facts

claimNutrient sensing pathways are identified as therapeutic targets for healthy ageing, according to a 2017 review in Expert Opinion on Therapeutic Targets.

claimMetabolic disturbance drives the functional decline of adult stem cells during aging, with nutrient-sensitive signaling pathways like mTOR and AMPK playing a central role.

claimMetformin contributes to metabolic-induced rejuvenation by regulating nutrient-sensitive signaling pathways.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

referenceEfeyan A, Comb WC, and Sabatini DM authored 'Nutrient-sensing mechanisms and pathways', published in Nature in 2015 (517:302–10, doi: 10.1038/nature14190).