concept

nonalcoholic fatty liver disease

Also known as: NAFLD, nonalcoholic fatty liver disease, non-alcoholic fatty liver disease, Nonalcoholic fatty liver disease

Facts (12)

Sources

Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Frontiers Jul 1, 2024 4 facts

referenceNon-invasive biomarkers for liver inflammation in non-alcoholic fatty liver disease are discussed in a 2023 supplement of Clinical and Molecular Hepatology.

claimInflammation is associated with the morbidity and mortality of cardiovascular disease, chronic kidney disease, diabetes mellitus, non-alcoholic fatty liver disease, cancer, autoimmune diseases, neurodegenerative disorders, and behavioral health disorders.

claimResearch by Liu et al. suggests that inflammation's clinical significance in nonalcoholic fatty liver disease (NAFLD) may assist in improving diagnosis and treatment options.

claimThe risk of nonalcoholic fatty liver disease (NAFLD) is linearly associated with the inflammation-related biomarkers systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR), and non-linearly associated with platelet-to-lymphocyte ratio (PLR) when natural logarithm transformed, according to Liu et al.

Chronic inflammation in the etiology of disease across the life span nature.com Nature Dec 5, 2019 2 facts

referenceMacrophages play a significant role in the pathogenesis of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

claimSystemic chronic inflammation (SCI) leads to several diseases that represent the leading causes of disability and mortality worldwide, including cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, and autoimmune and neurodegenerative disorders.

Western diet – Knowledge and References - Taylor & Francis taylorandfrancis.com Melissa G. Hunt, Aaron T. Beck · Taylor & Francis 2 facts

claimDramatic changes in diet and lifestyle over the last century have contributed to an increase in non-communicable diseases, including obesity, diabetes, nonalcoholic fatty liver disease, and irritable bowel syndrome (IBS).

claimLong-term consumption of high-fat and high-carbohydrate foods, characteristic of the Western diet, is associated with obesity, insulin resistance, hypertriglyceridemia, non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH), as well as inflammatory and oxidative stress conditions.

What is Inflammation? Causes, Effects, Treatment - Harvard Health health.harvard.edu Harvard Health Publishing Mar 27, 2023 2 facts

claimNonalcoholic fatty liver disease is fatty liver not caused by alcohol intake and consists of two types: simple fatty liver and nonalcoholic steatohepatitis (NASH).

claimNonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease that occurs when fattened liver cells become inflamed.

Homeostatic medicine: a strategy for exploring health and disease link.springer.com Springer Sep 26, 2022 1 fact

claimOral administration of inorganic compounds can directly regulate the M1/M2 ratio of macrophages, which helps prevent non-alcoholic fatty liver disease.

Paleolithic diet - Wikipedia en.wikipedia.org Wikipedia 1 fact

referenceThe article 'Hype or Reality: Should Patients with Metabolic Syndrome-related NAFLD be on the Hunter-Gatherer (Paleo) Diet to Decrease Morbidity?' published in the Journal of Gastrointestinal and Liver Diseases in 2015 examines the efficacy of the Paleolithic diet for patients with non-alcoholic fatty liver disease.