concept

neurite outgrowth

Also known as: neurite extension, neurite outgrowth, neurite growth

Facts (13)

Sources

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 13 facts

claimRueda et al. (2002) reported that a 24-hour in vitro exposure to the endocannabinoid AEA (5 µM) reduced neurite growth in cells via ERK signaling, and a four-day in vivo exposure to M-AEA (daily 5 mg/kg) decreased survival rates of adult-born granule cells in adult rats.

claimKetamine exhibits a dual profile regarding neurogenesis and neural plasticity: it promotes synaptogenesis, neurite growth, and new neuron formation in single-dose paradigms, but high doses or neonatal exposure are linked to neurogenesis impairment and long-term cognitive deficits.

claimTrkA is necessary for neurite extension in human neuroblastoma SK-N-SH cells.

claimZhou and Song (2001) demonstrated that acute exposure of neuroblastoma N1E-115 cells to HU210 (0.01–100 nM) dampened neurite growth in a dose-dependent manner, mediated by intracellular cAMP.

claimThe hallucinogen 2,5-dimethoxy-4-iodoamphetamine hydrochloride activates neurotrophin receptors in a neuronal cell line and promotes neurite extension.

claimNeurotrophic factors induce neurite growth, synaptic remodeling, neurogenesis, and oxidative stress reduction.

claimShum et al. (2020) proposed that CB1 receptor-mediated dampening of neurite growth involves ERK and Akt signaling pathways, and demonstrated that the neurite growth ratio could be restored to control levels by the CB1 antagonist SR141716 in human-induced pluripotent stem cell-derived neurons.

claimShum C, Dutan L, Annuario E, Warre-Cornish K, Taylor SE, Taylor RD, Andreae LC, Buckley NJ, Price J, Bhattacharyya S, and Srivastava DP demonstrated that delta-9-tetrahydrocannabinol (THC) and 2-AG decrease neurite outgrowth and differentially affect ERK1/2 and Akt signaling in human induced pluripotent stem cell (hiPSC)-derived cortical neurons.

measurementKetamine enhances synaptogenesis and neurite growth in young adult mice when administered at subanaesthetic doses ranging from 0.25 to 10 mg/kg/day.

claimOlanzapine prevents the PCP-induced reduction in the neurite outgrowth of prefrontal cortical neurons via NRG1, as shown in a 2016 study in Scientific Reports.

claimDunlap and colleagues demonstrated that the compounds isoDMT and 5-MeO-isoDMT enhance neurite growth in cultured cortical neurons, similar to their natural counterparts.

claimKetamine increases BDNF levels, which promotes synaptogenesis, neurite growth, and neurogenesis.

claimCannabinoid CB1 receptor activation stimulates neurite outgrowth and inhibits capsaicin-induced calcium influx in an in vitro model of diabetic neuropathy, according to a 2009 study in Neuropharmacology.