concept

neural stem cells

Also known as: NCSs, NSCs, neural stem/progenitor cells, human neural stem cells, primordial neural stem cells

Facts (21)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 7 facts

claimClinical trials for treating amyotrophic lateral sclerosis with stem cells, such as NCT05306457, have been completed and yielded desired results using autologous mesenchymal stem cells, endogenous mesenchymal stem cell mobilization, neural stem cells, and T-cell vaccination combined with mesenchymal stem cell and neural stem cell therapy.

claimPTEN deficiency reprograms human neural stem cells towards a glioblastoma stem cell-like phenotype.

claimMetformin activation of AMPK suppresses AGE-induced inflammatory response in human neural stem cells (hNSCs), as reported in a 2017 study in Experimental Cell Research.

claimiPSC-derived LewisX+CXCR4+beta1-integrin+ neural stem cells improve the amyotrophic lateral sclerosis phenotype by preserving motor neurons and muscle innervation in human and rodent models, according to Nizzardo et al. in Human Molecular Genetics (2016).

claimThe depletion of PTEN in neural stem cells (NSCs) activates Paired Box 7 (PAX7), inducing the generation of glioblastoma stem cell-like cells that can lead to intracranial tumors in vivo.

claimStem cell sources implicated in Parkinson’s disease treatment include neural stem cells, human embryonic stem cells, induced pluripotent stem cells, and directly induced dopamine neurons.

claimThe single non-neural progenitor transcription factor Ptf1a can directly reprogram fibroblasts into neural stem cells, according to Xiao et al. in Nature Communications (2018).

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 6 facts

claimAn increase in reactive oxygen species (ROS), independent of oxidative phosphorylation (OXPHOS), promotes the differentiation of pluripotent stem cells and adult stem cells, including mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), and neural stem cells (NSCs).

claimPhysiological oxygen levels are present in the in vivo niches of adult stem cells, including hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), and neural stem cells (NSCs).

claimThe regulation of intracellular calcium is considered crucial for the physiological differentiation of pluripotent stem cells (PSCs) and adult stem cells, including mesenchymal stem cells (MSCs) and neural stem cells (NSCs).

claimAdult stem cells, including hematopoietic stem cells (HSCs) and neural stem cells (NSCs), depend on glycolysis for energy despite having low proliferative rates or being quiescent.

claimIncreased reactive oxygen species (ROS) levels and mitochondrial DNA (mtDNA) mutagenesis lead to defective neural stem cells (NSCs) and hematopoietic stem cells (HSCs).

claimDefects in neural stem cells and neurogenesis are increasingly identified as potential factors in aging and neurological diseases.

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 4 facts

claimThe adult rat hippocampus contains primordial neural stem cells, as identified by Palmer, Takahashi, and Gage in 1997.

referenceFibroblast growth factor-2 activates a latent neurogenic program in neural stem cells derived from diverse regions of the adult central nervous system, according to T.D. Palmer, E.A. Markakis, A.R. Willhoite, F. Safar, and F.H. Gage in a 1999 Journal of Neuroscience publication.

referenceIn the 2002 study 'Adult neurogenesis and neural stem cells of the central nervous system in mammals' published in the Journal of Neuroscience Research, Taupin and Gage examine adult neurogenesis and neural stem cells in the mammalian central nervous system.

referenceIn the 2002 study 'Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons' published in Nature Neuroscience, Song, Stevens, and Gage report that neural stem cells derived from the adult hippocampus develop the essential properties of functional central nervous system neurons.

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 2 facts

claimIn the context of the review, neurogenesis is defined as the process of generating new neurons through cell division, which includes proliferation (multiplication of neural stem or progenitor cells), differentiation (commitment of cells into specific neuronal lineages), migration (movement to designated locations), maturation (development of dendrites, axons, and synaptic capabilities), integration (incorporation into existing neural networks), and survival (persistence of these neurons within the neural circuitry).

claimIn rodents, adult neurogenesis is restricted to the olfactory bulb, driven by neural stem cells in the subventricular zone, and the dentate gyrus sub-region of the hippocampus, driven by radial glial-like cells.

Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org Genes & Development 1 fact

claimIn the central nervous system, refeeding stimulates hypothalamic neurons, which subsequently activate a subset of neural stem cells (NSCs) to proliferate and drive the production of specific neuronal subtypes, as reported by Paul et al. (2017).

Bioelectricity - The Levin Lab drmichaellevin.org drmichaellevin.org 1 fact

referenceThe H(+) vacuolar ATPase maintains neural stem cells in the developing mouse cortex.