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neural progenitor cells
Also known as: NPCs, adult neural progenitor cells, neural progenitors, neural progenitor cell, adult neuronal progenitor cells, neural stem/progenitor cells
Facts (14)
Sources
Rusty Gage, PhD - Salk Institute salk.edu 8 facts
referenceAdult neuronal progenitor cells transplanted to the adult brain are capable of survival and differentiation, as reported in a 1995 study published in the Proceedings of the National Academy of Sciences of the United States of America.
claimA 10-amino acid sequence of fibroblast growth factor 2 is sufficient to induce mitogenic activity on neural progenitor cells, as reported by Ray, Baird, and Gage in 1997.
referenceE.A. Markakis, T.D. Palmer, L. Randolph-Moore, P. Rakic, and F.H. Gage identified novel neuronal phenotypes derived from neural progenitor cells.
claimEpidermal growth factor and fibroblast growth factor-2 exert different effects on neural progenitors in the adult rat brain, according to Kuhn, Winkler, Kempermann, Thal, and Gage in 1997.
referenceNurr1, an orphan nuclear receptor, acts as a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain, as reported by K. Sakurada, M. Ohshima-Sakurada, T.D. Palmer, and F.H. Gage in a 1999 Development article.
referenceL.S. Shihabuddin, T.D. Palmer, and F.H. Gage reviewed the prospects for using neural progenitor cells as a therapy for neurodegenerative disease in a 1999 article in Molecular Medicine Today.
referenceFGF-2-responsive neuronal progenitors are present in both proliferative and quiescent regions of the adult rodent brain, as reported in a 1995 study in Molecular and Cellular Neurosciences.
referenceG. Dziewczapolski, D.C. Lie, J. Ray, F.H. Gage, and C.W. Shults studied the survival and differentiation of adult rat-derived neural progenitor cells transplanted into the striatum of hemiparkinsonian rats.
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 3 facts
claimNeural progenitor cells (NPCs) exhibit decreased free radical production compared to neuronal and astrocytic counterparts.
referenceNeural stem/progenitor cells exhibit a low requirement for oxidative metabolism that is independent of hypoxia inducible factor‐1alpha expression, as reported by Candelario et al. in the Journal of Neurochemistry in 2013.
claimMouse embryonic and adult neural progenitor cells (NPCs) activate the oxidative phosphorylation (OXPHOS) program during the initial stages of neurogenesis.
Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org 2 facts
claimInhibition of the glycolytic enzymes hexokinase (HK2) and lactate dehydrogenase (LDH) during normoxia results in proliferation defects in neural progenitor cells.
claimNeural stem/progenitor cells increase fatty acid oxidation during periods of quiescence and increase fatty acid synthesis after stem cell activation and during proliferative periods, as reported by Knobloch et al. (2013, 2017).
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Dec 19, 2024 1 fact
claimPrenatal NMDA receptor antagonism impairs the proliferation of neuronal progenitors, leading to fewer glutamatergic neurons in the prefrontal cortex of rats, as found by Toriumi et al. in a 2012 study published in Neuropsychopharmacology.