concept

nerve growth factor

Also known as: NGF

Facts (30)

Sources

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 30 facts

referenceGrafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord, according to a 1996 study published in Cell Transplantation.

referenceR.J. Mandel, Rusty Gage, D.G. Clevenger, S.K. Spratt, R.O. Snyder, and S.E. Leff demonstrated that nerve growth factor expressed in the medial septum via recombinant adeno-associated viral vector delivery protects cholinergic neurons from fimbria-fornix lesion-induced degeneration, as published in the 1999 Experimental Neurology.

referenceGrafting of nerve growth factor-producing fibroblasts reduces behavioral deficits in rats with lesions of the nucleus basalis magnocellularis, as demonstrated by A.J. Dekker, J. Winkler, J. Ray, L.J. Thal, and F.H. Gage in 1994.

referenceChronic human nerve growth factor infusion ameliorates synaptic loss in cognitively impaired aged rats, according to a 1995 study by Chen et al. in Neuroscience.

referenceFibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord, according to a 1994 study by Fagan, A.M. and Gage, F.H.

referenceF.H. Gage, M.H. Tuszynski, K.S. Chen, A.M. Fagan, and G.A. Higgins published a review on the function of nerve growth factor in the central nervous system in the Journal of Neuroscience in 1991.

referenceIntraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration in the adult primate brain, according to a 1996 study published in Gene Therapy.

referenceNerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury, as reported in a 1996 study published in Experimental Neurology.

referenceAdrenal chromaffin cells transdifferentiate in response to basic fibroblast growth factor and show directed outgrowth to a nerve growth factor source in vivo, as reported by Chalmers et al. in a 1995 Experimental Neurology study.

referenceDelayed treatment with nerve growth factor improves the acquisition of a spatial task in rats with lesions of the nucleus basalis magnocellularis, according to a 1992 study by Dekker, Gage, and Thal published in Neuroscience.

referenceYoshida, Kakihana, Chen, Ong, Baird, and Gage investigated the cytokine regulation of nerve growth factor-mediated cholinergic neurotrophic activity synthesized by astrocytes and fibroblasts in a 1992 study.

referenceR.J. Mandel, F.H. Gage, and L.J. Thal found that spatial learning in rats correlates with cortical choline acetyltransferase levels and can be improved with nerve growth factor (NGF) following nucleus basalis magnocellularis (NBM) damage, as reported in a 1989 study in Experimental Neurology.

referenceWinkler, J., Ramirez, G.A., Kuhn, H.G., Peterson, D.A., Day-Lollini, P.A., Stewart, G.R., Tuszynski, M.H., Gage, F.H., and Thal, L.J. observed reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites following the intraventricular administration of nerve growth factor in a 1997 study.

referenceSomatic gene transfer of nerve growth factor to the aged brain results in behavioral and morphological amelioration, according to a 1995 study by Chen and Gage in the Journal of Neuroscience.

referenceL.R. Williams, S. Varon, G.M. Peterson, K. Wictorin, W. Fischer, A. Bjorklund, and F.H. Gage found that continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection, as published in the Proceedings of the National Academy of Sciences in 1986.

referenceKawaja, Rosenberg, Yoshida, and Gage demonstrated that somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats in a 1992 study.

referenceC.H. Phelps, F.H. Gage, J.H. Growdon, F. Hefti, R. Harbaugh, M.V. Johnston, Z.S. Khachaturian, W.C. Mobley, D.L. Price, and M. Raskind reviewed the potential use of nerve growth factor to treat Alzheimer's disease in a 1989 article in Neurobiology of Aging.

referenceW. Fischer, K. Wictorin, A. Björklund, L.R. Williams, S. Varon, and F.H. Gage demonstrated that nerve growth factor ameliorates cholinergic neuron atrophy and spatial memory impairment in aged rats, as published in Nature in 1987.

referenceF.H. Gage, D.M. Armstrong, L.R. Williams, and S. Varon studied the morphological response of axotomized septal neurons to nerve growth factor in a 1988 paper published in the Journal of Comparative Neurology.

referenceAdrenal chromaffin cells cografted into the striatum with nerve growth factor-producing fibroblasts show enhanced survival and neuronal differentiation, as reported by Niijima et al. in a 1995 Journal of Neuroscience study.

referenceFibroblast growth factor and other cytokines cooperatively regulate the synthesis and secretion of nerve growth factor in fibroblasts and astrocytes, as reported by Yoshida and Gage in a 1992 Brain Research publication.

referenceG.A. Higgins, S. Koh, K.S. Chen, and F.H. Gage demonstrated in a 1989 Neuron study that nerve growth factor (NGF) induces NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat.

referenceReactive astrocytes serve as substrates for the growth of adult central nervous system axons when nerve growth factor levels are elevated, according to a 1991 study by Kawaja and Gage published in Neuron.

referenceNerve growth factor increases cortical acetylcholine release in rats with lesions of the nucleus basalis, according to a 1991 study by Dekker, Langdon, Gage, and Thal published in Neuroreport.

referenceW. Fischer, A. Björklund, K. Chen, and F.H. Gage demonstrated that nerve growth factor (NGF) improves spatial memory in aged rodents as a function of age, as published in Brain Research in 1991.

referenceBrain-derived neurotrophic factor and nerve growth factor affect remaining neurons in the lesioned nucleus basalis magnocellularis, as reported by Tuszynski, M.H., Peterson, D.A., Ray, J., Baird, A., Nakahara, Y., and Gage, F.H. in 1994.

referenceHellweg, R., Fischer, W., Hock, C., Gage, F.H., Björklund, A., and Thoenen, H. examined nerve growth factor levels and choline acetyltransferase activity in the brains of aged rats with spatial memory impairments, as published in Brain Research (1990).

referenceM.H. Tuszynski, G. Buzsaki, and F.H. Gage demonstrated in a 1990 Neuroscience study that nerve growth factor infusions combined with fetal hippocampal grafts enhance the reconstruction of the lesioned septohippocampal projection.

referenceNerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration, as reported by Kang, U.J., Fisher, L.J., Joh, T.H., O'Malley, K.L., and Gage, F.H. in 1993.

referenceYoshida, K. and Gage, F.H. demonstrated that fibroblast growth factors stimulate the synthesis and secretion of nerve growth factor by astrocytes, as published in Brain Research (1991).