concept

negative feedback mechanism

Also known as: negative feedback regulation, negative feedback regulation mechanism, negative feedback, negative feedback control

Facts (11)

Sources

Homeostasis: The Underappreciated and Far Too Often ... - Frontiers frontiersin.org Frontiers in Physiology 5 facts

referenceGoodman (1980) notes that the operating point or range of negative feedback regulation can be adjusted or overridden by higher levels of control, allowing organisms to adapt to changing external conditions.

claimNegative feedback regulation is a primary mechanism by which homeostasis is achieved in organisms.

claimNegative feedback regulation in the cardiovascular system buffers against transitory changes to maintain stable blood pressure on a beat-by-beat basis throughout the day despite changing environmental or behavioral conditions.

formulaNegative feedback regulation requires an odd number of dashed lines (inverse relationships) in the system diagram to maintain the controlled variable within a narrow range of the desired value.

referenceHomeostatic control of the internal environment involves more than simple negative feedback regulation, as hierarchical levels of command and control allow organisms to adapt to changing and hostile environments, according to Carpenter (2004).

Homeostasis and Feedback Loops | Anatomy and Physiology I courses.lumenlearning.com Lumen Learning 3 facts

claimThe control of blood sugar is an example of a negative feedback mechanism.

claimFailure of the negative feedback mechanism for blood glucose can result in high blood glucose levels, which cause various negative health effects.

claimThe human body maintains a constant internal temperature to optimize chemical processes using thermoregulation, which is a negative feedback mechanism.

Homeostatic medicine: a strategy for exploring health and disease link.springer.com Springer Sep 26, 2022 2 facts

claimNegative feedback regulation allows the body to maintain relatively stable blood pressure throughout the day despite environmental or behavioral changes.

claimThe feedback control theory in cybernetics corresponds to the negative feedback regulation mechanism found in homeostasis regulation.

Homeostasis and Health: From Balance to Change | Biological Theory link.springer.com Springer Oct 14, 2025 1 fact

claimThe cybernetic approach to homeostasis posits that systems maintaining relatively constant states rely on a negative feedback mechanism consisting of a setpoint, a comparator/integrator/controller, and effectors that are elicited when the regulated variable departs from the setpoint.