concept

naïve pluripotent stem cells

Also known as: naïve PSCs, PSCs, naïve pluripotency, naive human embryonic stem cells, naive pluripotency

Facts (11)

Sources

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 11 facts

claimThe conversion of primed pluripotent stem cells (PSCs) to naïve PSCs is facilitated by STAT3-mediated activation of mitochondrial respiration and the induction of oxidative phosphorylation (OXPHOS) genes following the down-regulation of LIN28.

referenceStat3 promotes mitochondrial transcription and oxidative respiration during the maintenance and induction of naive pluripotency in stem cells, according to Carbognin et al. (2016).

claimNaïve pluripotent stem cells (PSCs) correspond to the pre-implantation stage of embryo development, whereas primed pluripotent stem cells (PSCs) correspond to the post-implantation stage.

claimRecent studies have investigated the functional and molecular differences between naïve and primed pluripotent stem cell (PSC) states to understand the relevance of mitochondrial metabolism for pluripotency.

referenceThe metabolome regulates the epigenetic landscape during the transition from naive to primed human embryonic stem cells, as reported by Sperber et al. in 2015.

claimNaïve pluripotent stem cells (PSCs) exhibit higher oxidative phosphorylation (OXPHOS) activity than primed pluripotent stem cells (PSCs), despite being potentially less developmentally mature.

claimNaïve pluripotent stem cells (PSCs) exhibit a bivalent metabolism that relies on both glycolysis and oxidative phosphorylation (OXPHOS), and they also demonstrate increased glycolytic metabolism.

referenceZic3 and esrrb coordinate hybrid cellular metabolism to synergistically enhance the induction of naive pluripotency, as described by Sone et al. (2017).

claimNaïve pluripotent stem cells (PSCs) show higher oxidative phosphorylation (OXPHOS) activity than primed pluripotent stem cells (PSCs), yet naïve PSCs possess a less tubular and non-fused mitochondrial morphology compared to primed PSCs.

claimThe increase in oxidative phosphorylation (OXPHOS) observed in naïve pluripotent stem cells (PSCs) does not necessarily result in reduced glycolysis.

claimAlpha-ketoglutarate (aKG)-dependent DNA and histone methylation may promote naïve pluripotency.