concept

mTOR

Also known as: mammalian target of rapamycin, mTOR kinase

Facts (5)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 2 facts

claimmTOR mediates Wnt-induced epidermal stem cell exhaustion and aging, according to a 2009 study in Cell Stem Cell.

claimMetabolic disturbance drives the functional decline of adult stem cells during aging, with nutrient-sensitive signaling pathways like mTOR and AMPK playing a central role.

Modern Diet and its Impact on Human Health - Longdom Publishing longdom.org Longdom Publishing 1 fact

claimThe nutrient-sensing system, with the mammalian target of rapamycin (mTOR) as a major component, controls nutrition storage, distribution, and utilization in vivo, and disordered control of this system can lead to metabolic diseases and cancer.

Homeostatic medicine: a strategy for exploring health and disease link.springer.com Springer Sep 26, 2022 1 fact

claimNitrate upregulates the expression of cellular signaling pathways including MAPK, PI3K-Akt, mTOR, WNT, glutathione metabolism, and the cell cycle, which are involved in cell regeneration, cell metabolism, and disease progression.

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 1 fact

referenceAkinfiresoye and Tizabi (2013) investigated the antidepressant effects of combining AMPA and ketamine, specifically examining the role of hippocampal BDNF, synapsin, and mTOR.