concept

MRSA

Facts (26)

Sources

Medicinal plants: bioactive compounds, biological activities ... frontiersin.org Frontiers in Immunology 26 facts

claimThe rise of superbugs like MRSA, difficulties in treating device-related infections, and the adverse effects of high-dose antibiotic therapy create a detrimental loop that increases the demand for higher antibiotic dosages and worsens antibiotic resistance.

claimThe acetone extract from Smilax zeylanica leaves is used for the treatment of ulcers and targets methicillin-resistant Staphylococcus aureus (MRSA) by causing cellular membrane instability and disintegration through ionic/electrostatic interactions and deposition on the bilayer surface.

claimThe acetone extract from cinnamon leaves is used for the treatment of throat and skin infections and targets methicillin-resistant Staphylococcus aureus (MRSA) by binding to hydrophobic groups in the bacterial membrane due to the extract's hydrophobicity.

claimAgarwal et al. indicated that the ethanol extract of Phyllanthus emblica (Indian gooseberry) aerial parts targets Mycobacterium tuberculosis and MRSA via electrostatic interactions.

claimThe acetone extract from Syzygium praecox leaves is used for the treatment of skin infections and targets methicillin-resistant Staphylococcus aureus (MRSA) through ionic/electrostatic interactions with the cell membrane.

claimC. quadrangular extracts significantly decreased bacterial loads in MRSA-infected dermal lesions in murine models.

claimEl-Mahdy et al. (273) suggested that resveratrol and curcumin may serve as alternative treatment strategies for treating MRSA infections by diminishing toxin production.

measurementC. quadrangular extracts at doses of 0.625, 0.313, and 0.156 mg/ml eliminated pre-existing MRSA and MDRAB biofilms.

referenceEl-Mahdy et al. (2023) examined the effect of resveratrol and curcumin on the gene expression of toxins produced by methicillin-resistant Staphylococcus aureus (MRSA).

claimThe chloroform extract from Andrographis paniculata (green chireta) exhibits activity against Methicillin-resistant Staphylococcus aureus (MRSA).

claimMethicillin-resistant Staphylococcus aureus (MRSA) resists β-lactam antibiotics, including methicillin, isoxazolyl penicillin, and cephalosporins, by acquiring the mecA gene, which produces penicillin-binding protein 2a to modify its target site.

claimLivestock-associated MRSA (LA-MRSA) occurs when individuals with MRSA transmit the bacterium to animals, or vice versa, and it has been identified in many animal species.

claimHospital-acquired MRSA (HA-MRSA) is defined as an MRSA infection identified when a positive culture is obtained more than 48 hours after a patient's hospital admission, and it is managed in a hospital environment.

claimThe acetone extract of the leaves of Smilax zeylanica and Syzygium praecox shows antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) by compromising cellular membranes via ionic and electrostatic interactions.

claimMRSA and MDR Acinetobacter baumannii (MDRAB) pose substantial challenges because their ability to acquire resistance to commonly utilized antibiotics enables them to induce chronic infections and impede the healing process.

claimCommunity-acquired MRSA epidemics have been associated with various populations, including athletes, inmates, prospective military personnel, nursery attendees, injectable drug users, individuals exchanging contaminated commodities, and residents of densely populated areas.

referenceMoellering RC Jr. authored 'MRSA: the first half century', published in the Journal of Antimicrobial Chemotherapy in 2012.

claimEthanol extract from amla aerial parts is used as an anti-diabetic, antioxidant, and anti-inflammatory agent, acting against Mycobacterium tuberculosis and MRSA via electrostatic interactions.

claimExtracts from C. quadrangular or its constituents can diminish biofilm adherence and the pathogenicity of MRSA and MDRAB, potentially serving as a topical antibacterial treatment for MRSA skin infections.

claimEugenol derived from Syzygium aromaticum (clove) exhibits antibacterial properties against Staphylococcus aureus ATCC 29213 and MRSA clinical isolates, and it impedes biofilm production.

claimThe ethanol extract from orange jessamine leaves is used for the treatment of cardiovascular disorders and targets methicillin-resistant Staphylococcus aureus (MRSA) through the hydrophobicity of the extract.

measurementThe minimum inhibitory concentration (MIC) range of berberine against diarrhea-associated bacteria, such as Staphylococcus aureus, MRSA, Vibrio cholera, Bacillus cereus, and Escherichia coli, is 12.5–469 µg/ml.

claimAntimicrobial studies have demonstrated that tea tree oil (derived from Melaleuca alternifolia) exhibits antibacterial activity against Staphylococcus aureus and MRSA in both in vitro and human trials.

claimThe methanol extract from stiff bottlebrush leaves exhibits activity against Methicillin-resistant Staphylococcus aureus (MRSA).

claimThe use of non-lactam antibiotics for treating Staphylococcus aureus infections has increased due to the rise of antibiotic-resistant bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA).

procedureAyaz et al. (271) examined the interaction mechanism between various chemical combinations and MRSA and E. coli using checkerboard dilution and time-kill curve assays.