concept

monoamine oxidase inhibitors

Also known as: MAO inhibitors, MAOIs, monoamine oxidase inhibitor, monoamine oxidase inhibitors (MAOis)

Facts (10)

Sources

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 6 facts

claimHarmala alkaloids act as monoamine oxidase inhibitors (MAOIs) and influence serotonin signaling similarly to selective serotonin reuptake inhibitors (SSRIs), allowing for dynamic regulation of BDNF levels.

claimMonoamine oxidase (MAO) inhibitors have specific risks, benefits, and lore, as detailed by Wimbiscus, Kostenko, and Malone in a 2010 article in the Cleveland Clinic Journal of Medicine.

referenceMcKenna, Towers, and Abbott (1984) published a study in the Journal of Ethnopharmacology identifying monoamine oxidase inhibitors, specifically tryptamine and β-carboline constituents, within the South American hallucinogenic plant preparation Ayahuasca.

claimThe monoamine oxidase inhibitor Phenelzine is used in the treatment of depressive-anxiety states, as discussed by Robinson in the Archives of General Psychiatry (1973).

claimWhile the antidepressant potential of monoamine oxidase inhibitors (MAOis) is well-established, further research is required to understand the side effects of harmala alkaloids (Wimbiscus et al. 2010).

perspectiveFuture research on harmala alkaloids should focus on long-term safety, comparisons with synthetic monoamine oxidase inhibitors (MAOis), and the potential for hepatotoxicity and interactions with tyramine-rich foods.

the consumption of psychoactive plants in ancient global and ... academia.edu Academia.edu 1 fact

claimPeganum harmala contains monoamine oxidase (MAO) inhibitors, which likely facilitated the psychoactive effects of other plants in ancient Anatolian religious rituals.

Diagnosis and Management of Generalized Anxiety Disorder ... - AAFP aafp.org American Academy of Family Physicians May 1, 2015 1 fact

claimMonoamine oxidase inhibitors used for anxiety disorders include isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate).

Medicinal plants and human health: a comprehensive review of ... link.springer.com Springer Nov 5, 2025 1 fact

claimHerbs can impact blood glucose control when used with antidiabetic drugs and can cause dangerous hypertensive reactions when combined with monoamine oxidase inhibitors (MAOIs).

Neuroimaging in psychedelic drug development: past, present, and ... nature.com Nature Sep 27, 2023 1 fact

referenceC.T. Ramachandraih, N. Subramanyam, K.J. Bar, G. Baker, and V.K. Yeragani published 'Antidepressants: From MAOIs to SSRIs and more' in the Indian Journal of Psychiatry in 2011, detailing the evolution of antidepressant medications.