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modafinil
Facts (13)
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Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 13 facts
claimPharmacological treatment for daytime sleepiness in narcolepsy with cataplexy involves modafinil or amphetamine-like stimulants, which likely function by increasing dopamine transmission.
claimFor individuals unable to avoid extended work hours or shift work, behavioral tips for alertness are available (NSF, 2005c), as well as wake-promoting medications including caffeine, modafinil, and sympathomimetic medications like pemoline and methylphenidate (Mitler and O’Malley, 2005).
claimModafinil is not approved by the U.S. Food and Drug Administration (FDA) for the treatment of sleep loss.
claimModafinil is the only drug approved by the U.S. Food and Drug Administration (FDA) for the treatment of shift work sleep disorder.
claimMany patients with Parkinson’s disease require daytime stimulants, such as modafinil or amphetamine, to relieve excessive sleepiness.
claimExcessive daytime sleepiness, including sleep attacks, has been associated with the use of dopamine agonists in patients with Parkinson’s disease, often requiring the use of daytime stimulants such as modafinil or amphetamine to relieve the sleepiness.
measurementIn a randomized clinical trial, caffeine and modafinil demonstrated similar benefits for performance and alertness.
claimThere have been no large-scale clinical trials examining the safety and efficacy of modafinil or other drugs for sleep loss in children and adolescents.
claimThe treatment of narcolepsy without cataplexy and idiopathic hypersomnia utilizes compounds similar to those used for narcolepsy with cataplexy, most notably modafinil and amphetamine-like stimulants (Billiard and Dauvilliers, 2001).
claimWake-promoting medications available for managing sleep loss include caffeine, modafinil, and sympathomimetic medications (direct and indirect acting), such as pemoline and methylphenidate.
claimA study by Wesensten et al. (2002) compared the efficacy of modafinil versus caffeine in maintaining alertness and performance during periods of sleep deprivation.
claimWesensten, Belenky, Kautz, Thorne, Reichardt, and Balkin compared the efficacy of modafinil versus caffeine in maintaining alertness and performance during sleep deprivation.
referenceBroughton RJ et al. conducted a randomized, double-blind, placebo-controlled crossover trial of modafinil for treating excessive daytime sleepiness in narcolepsy, published in Neurology in 1997.