concept

mitochondrial unfolded protein response

Also known as: UPRmt, mitochondrial UPR

Facts (7)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 7 facts

referenceAngeli, S. et al. published a study in 2021 titled 'The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging' in eLife, which establishes that the mitochondrial permeability transition pore triggers the mitochondrial unfolded protein response and contributes to the aging process.

referenceShpilka, T. and Haynes, C. M. published a study in 2018 titled 'The mitochondrial UPR: mechanisms, physiological functions and implications in ageing' in Nature Reviews Molecular Cell Biology, which reviews the mechanisms, physiological functions, and aging-related implications of the mitochondrial unfolded protein response.

referenceMunoz-Carvajal, F. and Sanhueza, M. published a study in 2020 titled 'The mitochondrial unfolded protein response: a hinge between healthy and pathological aging' in Frontiers in Aging Neuroscience, which describes the mitochondrial unfolded protein response as a critical factor distinguishing healthy aging from pathological aging.

claimTian et al. (2016) demonstrate that mitochondrial stress induces chromatin reorganization to promote longevity and the mitochondrial unfolded protein response (UPR(mt)).

referenceZhu, L., Luo, X., Fu, N., and Chen, L. published a study in 2021 titled 'Mitochondrial unfolded protein response: a novel pathway in metabolism and immunity' in Pharmacological Research, which characterizes the mitochondrial unfolded protein response as a pathway involved in metabolism and immunity.

referenceZhu, L., Zhou, Q., He, L., and Chen, L. published a study in 2021 titled 'Mitochondrial unfolded protein response: an emerging pathway in human diseases' in Free Radical Biology and Medicine, which identifies the mitochondrial unfolded protein response as a pathway relevant to human diseases.

referenceSoo, S. K., Traa, A., Rudich, P. D., Mistry, M., and Van Raamsdonk, J. M. published a study in 2021 titled 'Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors' in Life Science Alliance, which demonstrates that activating the mitochondrial unfolded protein response provides protection against various exogenous stressors.