concept

METTL3

Also known as: methyltransferase-like 3

Facts (8)

Sources

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 8 facts

referenceLi et al. (2017) reported in the Journal of Cellular Biochemistry that NSUN2-mediated m5C methylation and METTL3/METTL14-mediated m6A methylation cooperatively enhance p21 translation.

referenceWu et al. (2020) reported in Nucleic Acids Research that the enzyme METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.

referenceThe article 'Emerging role of METTL3 in inflammatory diseases: mechanisms and therapeutic applications' published in Frontiers in Immunology in 2023 examines the function of METTL3 in inflammatory conditions.

referenceSang et al. (2022) reported in the Journal of Cancer that the m6A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia.

referenceThe article 'Roles of METTL3 in cancer: mechanisms and therapeutic targeting' published in the Journal of Hematology & Oncology in 2020 discusses the mechanisms of the METTL3 protein in cancer and its potential as a therapeutic target.

referenceWang et al. (2024) reported in Cell Death Discovery that METTL3-mediated m6A modification increases Hspa1a stability, which inhibits osteoblast aging.

referenceChen et al. (2024) reported in Oncogene that METTL3 promotes cellular senescence of colorectal cancer via modulation of CDKN2B transcription and mRNA stability.

referenceLiu P, Liu F, Lin J, Fukumoto T, Nacarelli T, Hao X et al. reported in Nature Cell Biology (2021) that m6A-independent genome-wide redistribution of METTL3 and METTL14 drives the senescence-associated secretory phenotype.