concept

METTL14

Facts (6)

Sources

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 6 facts

referenceLi et al. (2017) reported in the Journal of Cellular Biochemistry that NSUN2-mediated m5C methylation and METTL3/METTL14-mediated m6A methylation cooperatively enhance p21 translation.

referenceThe article 'METTL14-mediated RNA methylation in digestive system tumors' published in the International Journal of Molecular Medicine in 2023 discusses the role of METTL14 in digestive system cancers.

referenceSang et al. (2022) reported in the Journal of Cancer that the m6A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia.

referenceLu et al. (2021) reported in Cell Death & Disease that METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1.

referenceThe article 'Functions, mechanisms, and therapeutic implications of METTL14 in human cancer' published in the Journal of Hematology & Oncology in 2022 reviews the role of the METTL14 protein in cancer.

referenceLiu P, Liu F, Lin J, Fukumoto T, Nacarelli T, Hao X et al. reported in Nature Cell Biology (2021) that m6A-independent genome-wide redistribution of METTL3 and METTL14 drives the senescence-associated secretory phenotype.