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m6A methylation
Also known as: m(6)A modification, m6A RNA modification, RNA m(6)A modification, m6A methylation, m6A modification
Facts (10)
Sources
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 8 facts
referenceLi et al. (2017) reported in the Journal of Cellular Biochemistry that NSUN2-mediated m5C methylation and METTL3/METTL14-mediated m6A methylation cooperatively enhance p21 translation.
referenceThe review 'The roles and implications of RNA m(6)A modification in cancer' published in Nature Reviews Clinical Oncology in 2023 discusses the impact of RNA m6A modification on cancer progression and clinical implications.
referenceThe study 'Lactylation of METTL16 promotes cuproptosis via m(6)A-modification on FDX1 mRNA in gastric cancer' published in Nature Communications in 2023 identifies that METTL16 lactylation promotes cuproptosis by modifying FDX1 mRNA in gastric cancer.
referenceRossi et al. (2024) reported in Nucleic Acids Research that increased PTCHD4 expression, driven by m6A modification of PTCHD4 mRNA, promotes senescent cell survival.
referenceWang et al. (2024) reported in Cell Death Discovery that METTL3-mediated m6A modification increases Hspa1a stability, which inhibits osteoblast aging.
referenceThe article 'Role of m6A modification in female infertility and reproductive system diseases' published in the International Journal of Biological Sciences in 2022 examines the impact of m6A modification on reproductive health.
claimThe GLORI method allows for the absolute quantification of single-base m6A methylation in the mammalian transcriptome.
referenceThe review 'm(6)A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer' published in Cancer Cell in 2020 examines the function of m6A modification in both coding and non-coding RNAs within the context of cancer.
Hallmarks and mechanisms of cellular senescence in aging ... - Nature nature.com Aug 4, 2025 1 fact
claimMin et al. (2018) identified an age-associated regulation of AGO2 mRNA stability through the profiling of m6A RNA modifications, as published in Aging Cell.
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 1 fact
claimXiong et al. (2021) report that RNA m(6)A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability.