concept

luteolysis

Facts (10)

Sources

The Normal Menstrual Cycle and the Control of Ovulation - NCBI - NIH ncbi.nlm.nih.gov Feingold KR, Adler RA, Ahmed SF · National Center for Biotechnology Information Aug 5, 2018 7 facts

claimEstrogen administration can induce luteolysis in humans, according to a 1973 study by Gore, Caldwell, and Speroff published in the Journal of Clinical Endocrinology & Metabolism.

claimEstrogen is believed to play a role in the luteolysis of the corpus luteum.

claimMatrix metalloproteinases are involved in the process of luteolysis.

claimEstradiol injected into the ovary bearing the corpus luteum induces luteolysis, while no effect is noted after estradiol injection of the contralateral ovary.

claimIf pregnancy does not occur, the corpus luteum undergoes luteolysis under the influence of estradiol and prostaglandins and forms scar tissue called the corpus albicans.

claimMechanisms controlling corpus luteum function, particularly regarding the timing of luteolysis, have been studied in sheep, cows, nonhuman primates, and women, according to a 1988 review by Auletta and Flint published in Endocrine Reviews.

claimIf pregnancy does not occur, the corpus luteum undergoes luteolysis under the influence of estradiol and prostaglandins, forming scar tissue known as the corpus albicans.

Unknown source 3 facts

referenceF.J. Auletta and A.P. Flint published 'Mechanisms controlling corpus luteum function in sheep, cows, nonhuman primates, and women especially in relation to the time of luteolysis' in Endocrine Reviews in 1988.

claimProstaglandin F2α induces luteolysis by stimulating the synthesis of endothelin-1, which inhibits steroidogenesis and triggers the release of tumor necrosis factor alpha (TNFα) to induce cell apoptosis.

referenceB.Z. Gore, B.V. Caldwell, and L. Speroff published 'Estrogen-induced human luteolysis' in the Journal of Clinical Endocrinology & Metabolism in 1973.