concept

lentiviral vectors

Also known as: lentiviral vector, lentivirus vectors, HIV-based lentiviral vectors

Facts (8)

Sources

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 7 facts

referenceTal Kafri, Henriette van Praag, Rusty Gage, and Inder M. Verma published 'Lentiviral vectors: regulated gene expression' in Molecular Therapy in 2000.

claimLentiviral vectors can achieve sustained expression of genes when delivered directly into liver and muscle tissue, as demonstrated by Kafri, Blömer, Peterson, Gage, and Verma in 1997.

referenceLentiviral vectors allow for in vivo gene delivery and stable transduction of nondividing cells, as reported in a 1996 study published in Science.

referenceT. Kafri, H. van Praag, L. Ouyang, Rusty Gage, and I.M. Verma developed a packaging cell line for lentivirus vectors, as published in the 1999 Journal of Virology.

claimLentivirus vectors enable highly efficient and sustained gene transfer in adult neurons, as demonstrated by Blömer, Naldini, Kafri, Trono, Verma, and Gage in 1997.

claimHIV-based lentiviral vectors allow for stable and efficient gene transfer into the retina, as reported by Miyoshi, Takahashi, Gage, and Verma in 1997.

referenceNaldini, L., Blömer, U., Gage, F.H., Trono, D., and Verma, I.M. demonstrated efficient transfer, integration, and sustained long-term expression of a transgene in adult rat brains using a lentiviral vector in a 1996 study.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 1 fact

claimIntravenous administration of lentiviral vectors containing Cas9/sg-KAT7 reduced liver ageing and increased lifespan in progeroid and physiologically old mice.