Knowledge Tree
ketogenic diet
Also known as: ketogenic diets
Facts (10)
Sources
Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org 9 facts
claimComparisons between caloric restriction/prolonged fasting, the ketogenic diet, and high-fat diets suggest the importance of the balance between glucose and fatty acid utilization as oxidative substrates in stem cells.
claimCaloric restriction induces a state of ketogenesis that is also recapitulated by a ketogenic diet.
claimIntestinal stem cells (ISCs) are highly enriched for the expression of 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), the rate-limiting enzyme for ketone biosynthesis, allowing them to engage in de novo ketogenesis even without a ketogenic diet.
measurementSystemic levels of β-hydroxybutyrate (β-OHB) increase to millimolar concentrations during fasting, caloric restriction, and ketogenic diets, largely due to hepatic production, as reported by Cahill et al. in 1966 and Shimazu et al. in 2013.
claimThe most thoroughly studied dietary interventions for altering organismal metabolism include caloric restriction, prolonged fasting, the ketogenic diet, and the high-fat “Western” diet.
claimThe ketogenic diet is a high-fat, low-carbohydrate diet originally developed to treat pediatric seizure disorders, as noted by Peterman (1924), Helmholz (1927), and Neal et al. (2008).
claimCaloric restriction, prolonged fasting, and the ketogenic diet elicit similar systemic changes to metabolic homeostasis, though they operate through slightly different mechanisms.
claimCirculating lipid availability increases under conditions of caloric restriction, the ketogenic diet, and Western diets, and the accompanying increased fatty acid oxidation provides insights into the convergence of phenotypes observed with these diets, as noted by Corton et al. (2004), Sikder et al. (2018), Steinhauser et al. (2018), and Rosenbaum et al. (2019).
referenceA month-long administration of a ketogenic diet enriches the small intestine for both Lgr5high intestinal stem cells (ISCs) and Lgr5low short-lived proliferative intestinal progenitors, without altering differentiated Paneth cell numbers, as reported by Cheng et al. in 2019.
Paleolithic diet - Wikipedia en.wikipedia.org 1 fact
measurementA 2019 analysis of diets in the United States ranked the consumption of a Paleolithic diet as more environmentally harmful than an omnivorous diet, though less harmful than a ketogenic diet.