concept

intracerebral neural grafting

Also known as: intracerebral transplantation, intracerebral grafting, intracerebral grafting of genetically modified cells, intracerebral neural grafting

Facts (11)

Sources

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 11 facts

claimRat dopamine neurons previously cultured in vitro are capable of survival after being grafted intracerebrally, according to Brundin et al. (1985).

referenceBjörklund, Gage, Stenevi, Dunnett, and Kelly reviewed strategies, rationale, and preliminary results for intracerebral neural grafting in animal models of the aging brain in a 1985 Experimental Brain Research publication.

referenceGage, F.H. discussed the use of intracerebral grafting of genetically modified cells to act as biological pumps, as published in Trends in Pharmacological Sciences (1990).

referenceGage, Kang, and Fisher reviewed the issues and controversies surrounding intracerebral grafting in the dopaminergic system in a 1991 article in Current Opinion in Neurobiology.

referenceGage and Björklund published a paper on the intracerebral grafting of neuronal cell suspensions into the adult brain in the 1984 journal Central Nervous System Trauma.

referenceA. Björklund, U. Stenevi, R.H. Schmidt, S.B. Dunnett, and F.H. Gage published 'Intracerebral grafting of neuronal cell suspensions. II. Survival and growth of nigral cell suspensions implanted in different brain sites' in Acta physiologica Scandinavica. Supplementum in 1983.

referenceF.H. Gage, M.B. Rosenberg, M.H. Tuszynski, K. Yoshida, D.M. Armstrong, R.C. Hayes, and T. Friedmann discussed gene therapy in the central nervous system, specifically the intracerebral grafting of genetically modified cells, in a 1990 Progress in Brain Research publication.

referenceF.H. Gage, P. Brundin, R. Strecker, S.B. Dunnett, O. Isacson, and A. Bjorklund studied intracerebral neuronal grafting in experimental animal models of age-related motor dysfunction in a 1988 paper published in the Annals of the New York Academy of Sciences.

referenceGage, Kawaja, and Fisher reviewed the applications of genetically modified cells for intracerebral grafting in a 1991 article in Trends in Neurosciences.

referenceGage, F.H. and Fisher, L.J. described intracerebral grafting as a tool for neurobiologists, as published in Neuron (1991).

referenceBrundin, P., Strecker, R.E., Gage, F.H., Lindvall, O., and Björklund, A. investigated the intracerebral transplantation of dopamine neurons to understand the functional role of the mesolimbocortical dopamine system and to develop a therapy for Parkinson's disease.