concept

insulin-like growth factor 1

Also known as: IGF-I, insulin-like growth factor 1, insulin-like growth factor I, Insulin-like growth factor 1, IGF1, insulin-like growth factor-1, IGF-1

Facts (10)

Sources

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 3 facts

referenceB.K. Kaspar, J. Lladó, N. Sherkat, J.D. Rothstein, and F.H. Gage demonstrated that retrograde viral delivery of IGF-1 prolongs survival in a mouse model of Amyotrophic Lateral Sclerosis (ALS).

referenceM.A. Aberg, N.D. Aberg, T.D. Palmer, A.M. Alborn, C. Carlsson-Skwirut, P. Bang, L.E. Rosengren, T. Olsson, F.H. Gage, and P.S. Eriksson demonstrated that Insulin-like Growth Factor I (IGF-I) has a direct proliferative effect on adult hippocampal progenitor cells.

referenceJ. Hsieh, J.B. Aimone, B.K. Kaspar, T. Kuwabara, K. Nakashima, and F.H. Gage found that Insulin-like Growth Factor I (IGF-I) instructs multipotent adult neural progenitor cells to differentiate into oligodendrocytes.

The Normal Menstrual Cycle and the Control of Ovulation - NCBI - NIH ncbi.nlm.nih.gov Feingold KR, Adler RA, Ahmed SF · National Center for Biotechnology Information Aug 5, 2018 3 facts

claimGrowth factors such as insulin-like growth factor 1 (IGF1), insulin-like growth factor 2 (IGF2), and epidermal growth factor (EGF) play important roles in oocyte development and maturation.

referenceThierry van Dessel H.J. et al. published a study in 1996 in the journal J Clin Endocrinol Metab titled 'Serum and follicular fluid levels of insulin-like growth factor I (IGF-I), IGF-II, and IGF-binding protein-1 and -3 during the normal menstrual cycle', which measures growth factor levels across the menstrual cycle.

claimInsulin-like growth factor 1 (IGF1), insulin-like growth factor 2 (IGF2), and epidermal growth factor (EGF) play roles in oocyte development and maturation.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 2 facts

claimThe restoration of macrophage and fibroblast crosstalk through insulin-like growth factor 1 (IGF1) and platelet-derived growth factor C (PDGFC) can reduce tissue dysfunction caused by pathological healing and fibrosis.

claimPatel S. A., Chaudhari A., Gupta R., Velingkaar N., and Kondratov R. V. found that circadian clocks govern calorie restriction-mediated life span extension through BMAL1- and IGF-1-dependent mechanisms in a 2016 study published in The FASEB Journal.

“Manopause”: How Male Hormones Change With Age - JCMC jcmchealth.com JCMC Health Aug 2, 2022 1 fact

claimAs men age, they naturally experience a decrease in growth hormone (GH), prolactin, and insulin-like growth factor-1 (IGF-1) in addition to testosterone.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

referenceInsulin-like growth factor 1 (IGF-1) signaling plays a role in glucose metabolism in colorectal cancer, according to Kasprzak (2021).