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insulin/IGF-1 signaling pathway
Also known as: IIS, insulin/IGF-1, insulin/IGF-1 signaling
Facts (6)
Sources
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 4 facts
referenceJ. Papaconstantinou published 'Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination' in Molecular and Cellular Endocrinology in 2009, which discusses the interaction between insulin/IGF-1 and reactive oxygen species (ROS) signaling pathways in the context of aging and longevity.
referenceInsulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway, which impacts the aging process and age-related diseases, according to Salminen et al. (2021).
referenceV.N. Anisimov published 'Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention' in Experimental Gerontology in 2003, which explores the insulin/IGF-1 signaling pathway as a target for pharmacological intervention in aging and cancer.
referenceM.M. Rincon, R. Muzumdar, G. Atzmon, and N. Barzilai published 'The paradox of the insulin/IGF-1 signaling pathway in longevity' in Mechanisms of Ageing and Development in 2004, examining the role of the insulin/IGF-1 signaling pathway in longevity.
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 1 fact
referenceA specific PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans that have reduced insulin/IGF-1 signaling, according to a 2021 study in Nature Communications.
Antiageing strategy for neurodegenerative diseases - Nature nature.com Mar 10, 2025 1 fact
claimThe insulin/insulin-like growth factor 1 (IGF-1) signalling (IIS) pathway is the first identified and extensively validated age-regulating pathway.