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inorganic nitrate
Facts (16)
Sources
Homeostatic medicine: a strategy for exploring health and disease link.springer.com Sep 26, 2022 16 facts
referenceRoberts LD et al. demonstrated that inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway in a 2015 study published in Diabetes.
claimInorganic nitrate effectively relieved the decline of salivary gland function after radiation injury in rats.
claimInorganic nitrate maintains nitric oxide homeostasis via the nitrate-nitrite-nitric oxide pathway and has demonstrated beneficial effects in various cardiovascular diseases (Kapil et al. 2020b).
claimInorganic nitrate shows an inhibitory effect on radiation-induced oxidative stress even at low radiation intensities, such as those from cone-beam computed tomography (CBCT) examinations.
claimInorganic nitrate regulates nitric oxide (NO) homeostasis through the nitrate-nitrite-NO pathway and provides various beneficial physiological functions.
referenceJadert C, Petersson J, Massena S, Ahl D, Grapensparr L, Holm L, et al. published 'Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury' in Free Radical Biology and Medicine in 2012.
claimIn liver oxidative stress injury induced by ischemia-reperfusion, inorganic nitrate intake increases nitric oxide (NO) levels in the plasma and liver, relieving oxidative stress by upregulating nuclear factor erythroid 2-related factor 2 (NRF2)-related molecules and increasing antioxidant enzyme activity.
claimIn mice susceptible to atherosclerosis, inorganic nitrate intake rescues nitric oxide (NO) homeostasis, which inhibits neutrophil activation and increases IL-10 levels.
claimIn rats with xerostomia caused by ovariectomy, inorganic nitrate upregulated the expression of aquaporin-5 in the salivary glands, which increased salivary secretion and reduced fibrosis and acinous atrophy of salivary gland tissues, according to Xu et al. (2018).
claimInorganic nitrate intake reduces the number of macrophages in atherosclerotic plaques and inhibits their inflammatory activity by reversing nitric oxide (NO) deficiency caused by endothelial dysfunction.
referenceWang H et al. found that inorganic nitrate alleviates the senescence-related decline in liver function in a 2018 study published in Science China Life Sciences.
claimInorganic nitrate relieved colitis in rats after systemic radiation by regulating the homeostasis of intestinal flora.
claimInorganic nitrate treatment showed more significant hypotensive effects in hypertensive patients with impaired endothelial function compared to healthy volunteers, suggesting it may help ameliorate endothelial homeostasis disorders (Kapil et al. 2015).
claimInorganic nitrate does not exhibit the same drug resistance as organic nitrate, as evidenced by a significant antihypertensive effect observed after one year of use (Munzel et al. 2005).
claimOral administration of inorganic nitrate alleviated biological damage induced by cone-beam computed tomography examination in Wistar rats.
claimInorganic nitrate improves the sensitivity of oral squamous cell carcinoma to chemotherapy by decreasing the expression of REDD1 (regulated in development and DNA damage responses 1), which is associated with improved NO homeostasis in hypoxic tumor tissues.