concept

inflammaging

Also known as: inflamm-aging, inflammageing, Inflammageing

Facts (10)

Sources

Chronic inflammation in the etiology of disease across the life span nature.com Nature Dec 5, 2019 4 facts

claimFerrucci, L. and Fabbri, E. (2018) define 'inflammageing' as chronic inflammation associated with aging, cardiovascular disease, and frailty.

claimInflammaging is characterized as a new immune-metabolic viewpoint for understanding age-related diseases, as proposed in a 2018 article in Nature Reviews Endocrinology.

claimThe phenomenon of 'inflamm-aging' does not simply reflect increases in pro-inflammatory markers, as noted in a 2014 study published in Mechanisms of Ageing and Development.

referenceInflammaging and 'garb-aging' are concepts describing age-related inflammatory processes.

A Double-Edged Sword: Inflammation and Your Health - Cedars-Sinai cedars-sinai.org Cedars-Sinai Feb 12, 2021 2 facts

quote"Inflammaging is a sort of chronic, nagging inflammatory response that doesn't fight anything. Instead, it builds up over time, damaging tissues."

claimInflammaging is defined as a chronic, nagging inflammatory response that accumulates over time and damages tissues without fighting pathogens.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 2 facts

referenceRoyce, G. H., Brown-Borg, H. M., and Deepa, S. S. published a study in 2019 titled 'The potential role of necroptosis in inflammaging and aging' in Geroscience, which explores the potential involvement of necroptosis in the processes of inflammaging and aging.

claimInflammageing is a prominent and important change in intercellular signaling that occurs with age.

Homeostatic medicine: a strategy for exploring health and disease link.springer.com Springer Sep 26, 2022 1 fact

referenceFulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. published 'Immunosenescence and Inflamm-aging as two sides of the same coin: friends or foes?' in Frontiers in Immunology in 2017, which discusses the relationship between immunosenescence and inflamm-aging.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

referenceInflammageing and immunosenescence are interconnected during the aging process, as described by Teissier et al. in a 2022 article in Cells.