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in vivo cellular reprogramming
Also known as: in vivo lineage reprogramming, direct in vivo reprogramming, in vivo cellular reprogramming, in vivo reprogramming
Facts (16)
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Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 16 facts
claimMelendez et al. found that natural killer cells act as an extrinsic barrier for in vivo reprogramming, as reported in Development in 2022.
claimIn situ regeneration based on in vivo reprogramming is currently being applied to regenerate pancreatic β cells, induced cardiomyocyte-like cells, expandable neural stem cells, and sensory hair cells.
referenceSrivastava and DeWitt (2016) discuss in vivo cellular reprogramming as the next generation of research in the journal Cell.
referenceChiche et al. (2017) report that injury-induced senescence enables in vivo reprogramming in skeletal muscle, as published in Cell Stem Cell.
claimApproaches for treating diabetes by targeting senescent β cells include novel drugs for antagonizing β cell senescence, regulating metabolic burden to protect β cell function, inhibiting islet inflammation, in vivo reprogramming for β cell regeneration, and epigenetic modifications to rejuvenate senescent β cells.
referenceIn vivo reprogramming of pancreatic ducts leads to the long-term correction of diabetes in mice, as described by Fu et al. in Molecular Therapy (2018).
claimIn vivo reprogramming faces challenges in systemic delivery, leading some researchers to focus on local rejuvenation strategies.
claimIn vivo reprogramming is currently in its early stages of development and faces significant technical bottlenecks.
claimHeart-specific in vivo reprogramming induces adult cardiomyocytes to a fetal state, conferring regenerative capacity and reducing myocardial infarction-induced damage.
referenceIn vivo reprogramming can be utilized for tissue regeneration and organismal rejuvenation, as discussed in a 2017 review by Park et al. in Current Opinion in Genetics & Development.
claimIn vivo reprogramming is a potential avenue for facilitating tissue repair.
referenceIn vivo reprogramming of immune cells can be used as a technology for the induction of antigen-specific tolerance.
claimSadahiro, T. and Ieda, M. proposed in vivo reprogramming as a new approach to cardiac regenerative therapy.
claimTeratoma formation is a potential limitation of in vivo reprogramming, which may be caused by excessive OSKM dosage.
referenceIn vivo reprogramming of wound-resident cells can generate skin epithelial tissue.
claimIn vivo reprogramming with short-term cyclic expression of OSKM inhibits the progression of intervertebral disc degeneration and improves senescence-associated phenotypes in ageing nucleus pulposus cells.