concept

IgG

Also known as: Ig, Immunoglobulin G

Facts (14)

Sources

Parts of the Immune System | Children's Hospital of Philadelphia chop.edu Children's Hospital of Philadelphia 6 facts

claimIgM antibodies are less effective than IgG antibodies that appear later during an infection, though they are specific for the pathogen.

measurementTypical adults have more than 70 grams (or 17 teaspoons) of IgG circulating in their bloodstream every day.

claimIgG antibodies circulate in the spaces between tissues and are shared across the placenta during pregnancy.

claimThere are five classes of antibodies (immunoglobulins) in humans: IgG, IgM, IgA, IgE, and IgD.

claimIgM antibodies exist as a pentamer, meaning five IgM molecules travel together, which prevents them from leaving the blood to enter tissues like IgG antibodies.

claimIgG is the most abundant antibody class found in human blood and tissues, with four identified subcategories.

How the Immune System Works with Primary Immunodeficiency igcares.com IGCares 2 facts

claimThere are five major classes of antibodies: IgG, IgA, IgM, IgD, and IgE.

claimIgG has four subclasses (IgG1, IgG2, IgG3, and IgG4), and IgA has two subclasses (IgA1 and IgA2).

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

referenceYu, L., Wan, Q., Liu, Q., Fan, Y., Zhou, Q., Skowronski, A.A., et al. published a study in 2024 in Cell Metabolism titled 'IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline', identifying IgG as a factor that drives adipose tissue fibrosis and metabolic decline.

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com Thermo Fisher Scientific 1 fact

referenceIL-4 is classified as an adaptive immunity cytokine, is produced by Th cells, binds to the CD124 receptor, targets B cells, T cells, and macrophages, and functions in the proliferation of B and cytotoxic T cells, enhancement of MHC class II expression, and stimulation of IgG and IgE production.

Neuroanatomy, Neuron Action Potential - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov National Library of Medicine 1 fact

procedureDiagnosis of Multiple Sclerosis (MS) can be aided by testing for oligoclonal bands of IgG in cerebrospinal fluid using electrophoresis.

The components of the immune system - Immunobiology - NCBI - NIH ncbi.nlm.nih.gov Janeway CA Jr, Travers P, Walport M · Garland Science 1 fact

claimAntibody molecules are known as immunoglobulins (Ig), and the antigen receptor of B lymphocytes is known as membrane immunoglobulin (mIg).

3. The Innate Immune System - Immunopaedia immunopaedia.org.za Immunopaedia 1 fact

claimNatural Killer (NK) cells can kill target cells through antibody-dependent cellular cytotoxicity (ADCC), a hybrid mechanism where IgG molecules link the innate and adaptive immune systems.

Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu Linus Pauling Institute 1 fact

claimVitamin A-deficient mice show contrasting impairments in IgM and IgG antibody responses, as demonstrated in a 1987 study by Smith and Hayes published in the Proceedings of the National Academy of Sciences of the United States of America.