concept

human induced pluripotent stem cells

Also known as: iPSCs, hiPSC, human iPSCs, human iPS cells, induced pluripotent stem cells, human induced pluripotent stem cell, human induced pluripotent stem cell lines

Facts (11)

Sources

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 7 facts

referenceEsteban et al. (2010) reported that Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.

claimYokota et al. (2017) found that mitochondrial respiratory dysfunction disturbs the neuronal and cardiac lineage commitment of human induced pluripotent stem cells, as published in 'Mitochondrial respiratory dysfunction disturbs neuronal and cardiac lineage commitment of human iPSCs' in Cell Death & Disease.

claimDannenmann et al. (2015) report that high levels of glutathione and glutathione peroxidase-2 mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells, as detailed in 'High glutathione and glutathione peroxidase‐2 levels mediate cell‐type‐specific DNA damage protection in human induced pluripotent stem cells' published in Stem Cells.

referenceLister R et al. identified hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells in 2011.

referencePrigione A et al. reported in 2011 that human induced pluripotent stem cells (iPSCs) harbor both homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining metabolic reprogramming similar to human embryonic stem cells (hESCs).

claimArmstrong et al. (2010) report that human induced pluripotent stem cell lines exhibit stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells, as detailed in 'Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells' published in Stem Cells.

referenceSharma et al. (2013) investigated the role of the SIRT6 protein in the aging and reprogramming of human induced pluripotent stem cells.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 3 facts

referencePrigione et al. (2010) state that the senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells, as published in the journal Stem Cells.

referenceTanaka et al. (2020) developed a high-efficacy reprogramming method for generating human induced pluripotent stem cells from pathologic and senescent somatic cells, as published in the International Journal of Molecular Sciences.

referenceDe Vos et al. (2016) describe human induced pluripotent stem cells as a disruptive innovation in the journal Current Research in Translational Medicine.

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 1 fact

claimShum C, Dutan L, Annuario E, Warre-Cornish K, Taylor SE, Taylor RD, Andreae LC, Buckley NJ, Price J, Bhattacharyya S, and Srivastava DP demonstrated that delta-9-tetrahydrocannabinol (THC) and 2-AG decrease neurite outgrowth and differentially affect ERK1/2 and Akt signaling in human induced pluripotent stem cell (hiPSC)-derived cortical neurons.