concept

histone deacetylase inhibitors

Also known as: HDAC inhibitors, histone deacetylase inhibitor, histone deacetylase inhibition, HDACi

Facts (5)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 3 facts

claimThe combination of cisplatin and a histone deacetylase inhibitor may synergistically suppress the progression of non-small cell lung cancer.

claimHistone deacetylase (HDAC) inhibitors can reverse the deacetylation of histone tails and trigger the expression of specific genes, contributing to the fight against ageing and age-related disorders.

referenceHDAC inhibitors are a promising drug class in anti-aging research, as discussed by Wang et al. in Mechanisms of Ageing and Development (2017).

Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org Genes & Development 2 facts

referenceButyrate is a more potent HDAC inhibitor than β-OHB.

referenceButyrate functions as an HDAC inhibitor.